Phase 4
Completed N=30
Examining the Effects of Antipsychotic Medications on Insulin Sensitivity
Source: ClinicalTrials.gov NCT00895921 ↗Enrolled (actual)
30
Serious AEs
0.0%
Results posted
Aug 2020
Primary outcomePrimary: Change in Glucose Disposition — 1.18; 1.42 ratio of post/pre values — p=0.042
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
This study will examine the effects of two different antipsychotic medications on control of blood sugar in people who are at risk of diabetes but mentally healthy.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Glucose Disposition |
1.18; 1.42 | 0.042 sig |
| SECONDARY Change in Percent of Insulin Suppression of Endogenous Glucose Production |
1.0594; 1.312 | 0.269 |
| SECONDARY Akathisia |
1; 7 | 0.012 sig |
Eligibility Criteria
Inclusion Criteria
- Prediabetic, defined as 2-hour post-load serum glucose between 140 and 199 mg/dl on a 75-gram standard oral glucose tolerance test (OGTT) within the past 90 days
- Family history of type 2 diabetes mellitus
- Body mass index (BMI) between 25 and 35 kg/m2
- English speaker
- Nonsmoker
Exclusion Criteria
- History of Axis I mood, anxiety, or psychotic disorder, confirmed by Structured Clinical Interview for DSM-IV
- Use of psychotropic drugs
Data sourced from ClinicalTrials.gov (NCT00895921). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.