N/A N=193 Randomized Basic Science

Immune Responses Induced by Different Licensed Influenza Vaccines

Immune Response

Bottom Line

View on ClinicalTrials.gov: NCT00902278 ↗

Enrolled (actual)

193

Serious AEs

0.0%

Results posted

Nov 2017

Primary outcome: Primary: T Cell Responses Following Immunization — 1.5; 1.7; 1.9; 1.6 fold change

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Flulaval (Biological); Fluvirin (Biological); Fluzone (Biological); Fluarix (Biological); Afluria (Biological)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: University of Massachusetts, Worcester
Primary completion: Apr 2016

Outcome Measures

Outcome	Result	p-value
PRIMARY T Cell Responses Following Immunization	1.5; 1.7; 1.9; 1.6; 2.4; 2.1	—
SECONDARY Antibody Responses Following Immunization	7.32; 7.02; 5.71; 5.26; 7.6; 7.2	—

Summary

The goal of this research is to find out how the body's immune system responds to different manufacturer's "flu" vaccines.

Eligibility Criteria

Inclusion Criteria

Adults (18-50 years of age)
Willing to donate a blood sample multiple times
Willing to sign informed consent and HIPAA

Exclusion Criteria

Known systemic hypersensitivity reactions to egg proteins (eggs or egg products), to chicken proteins
Known hypersensitivity to neomycin, thimerosol (mercury derivative), neomycin, or polymyxin
Previous life threatening reaction to influenza vaccine
Individuals with altered immunocompetence state from medical condition ( HIV, cancer) or through immunosuppressive therapy(irradiation,corticosteroids, antimetabolites, alkylating agents, cytotoxic agents)
Occurrence of neurological syndrome within six weeks of previous influenza immunization
Active neurological disorder characterized by changing neurological disorder
Pregnancy
Acute febrile illness
History of anemia or bleeding disorders

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00902278). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.