Prevalence of Hookworm Infection and Community Preparedness for Hookworm Vaccine Trials in Endemic Areas of Brazil

Inclusion Criteria

• Males and females between 6 and 45 years of age, inclusive, at the time of consenting to the parent study.
• Age greater than or equal to 18 years at the time of signing the supplemental informed consent document for the skin test procedure (parent study).
• Willingness to participate in the study as evidenced by signing the informed consent or assent document.

Exclusion Criteria

• Inability to correctly answer all questions on the informed consent comprehension questionnaire.
• Attends school or works full-time outside of the study area.
• Behavioral, cognitive, or psychiatric disease that in the opinion of the investigator affects the ability of the volunteer to understand and cooperate with the study protocol.
• Other condition that in the opinion of the investigator would jeopardize the safety or rights of a volunteer to participate in the trial or would render the subject unable to comply with the protocol.
• Pregnancy as determined by a positive urine hCG test (if female).
• Use of corticosteroids (excluding topical or nasal) or immunosuppressive drugs within 30 days of planned skin test application.
• Extensive dermatitis precluding skin testing.
• Current use of a beta blocker (oral or topical) or anti-histamine medication. A volunteer may participate in the study if they agree to withhold use of an anti-histamine for at least 5 days prior to application of the skin test.
• Use of a tricyclic anti-depressant within the past month.