N/A
Completed N=118
Light Treatment for Sleep/Wake Disturbances in Alzheimer's Disease
Sleep Initiation and Maintenance Disorders
Source: ClinicalTrials.gov NCT00946530 ↗
Enrolled (actual)
118
Serious AEs
0.0%
Results posted
Mar 2017
Primary outcomePrimary: Total Sleep Time — 393; 420; 398; 409 units on a scale (minutes)
Summary
The aim of this study is to demonstrate the efficacy of timed exposure to bright light for the treatment of disturbed nighttime sleep and daytime wake in community-dwelling dementia patients and their caregivers, and to determine if there are genetic relationships between memory problems and sleep problems
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Total Sleep Time |
393; 420; 398; 409 | — |
| SECONDARY WASO (Wake After Sleep Onset) |
124; 107; 63.4; 61.0 | — |
Eligibility Criteria
Inclusion Criteria:Alzheimer's Disease Patients:
- Stanford Alzheimer's Disease Core Center member or potential member, with diagnostic criteria met for probable AD, living with caregiver willing to participate in the protocol
- Non-institutionalized
Caregivers:
- Living in home of AD patient and willing to participate in protocol Exclusion Criteria:Alzheimer's Disease Patients:
- History of manic or bipolar disorder
- Prior bright light treatment
- Irregular or non-24 hour sleep/wake cycle
- Positive result on multi-staged RLS/PLMD
- Medical/Ophthalmologic Exclusions
- RDI >20 on overnight EdenTrace® recording
Caregivers:
- History of manic or bipolar disorder
- Medical/Ophthalmologic Exclusions
Data sourced from ClinicalTrials.gov (NCT00946530). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.