N/A
N=28
Exercise, Oxidative Stress and HIV
HIV Infections
Bottom Line
View on ClinicalTrials.gov: NCT00950937 ↗Enrolled (actual)
28
Serious AEs
—
Results posted
Aug 2009
Primary outcome: Primary: Total Glutathione — 1,964; 3,490; 1,865; 3,995 nmoles glutathione/ ml of sample — p=<0.05
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- —
- Age
- Adult · 20+ yrs
- Sex
- All
- Sponsor
- Hospital de Clinicas de Porto Alegre
- Primary completion
- Jan 2007
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Total Glutathione |
1,964; 3,490; 1,865; 3,995; 1,767; 3,206 | <0.05 sig |
| SECONDARY Catalase Activity |
0.578; 0.967; 1.03; 0.855; 0.566; 1.009 | <0.05 sig |
| SECONDARY Glutathione S-transferase (GST) |
0.34; 0.5; 0.34; 0.36; 0.45; 0.46 | <0.05 sig |
| SECONDARY Lipid Peroxidation |
2.356; 2.888; 2.328; 4.164; 2.348; 3.205 | <0.05 sig |
| SECONDARY T CD4 |
417; 984; 428; 968; 378; 974 | <0.05 sig |
| SECONDARY Neutrophil Count |
3,237; 3,212; 3,285; 3,476; 3,511; 3,563 | <0.05 sig |
| SECONDARY Peak Oxygen Uptake |
1,673; 2,167 | <0.05 sig |
Summary
The purpose of this study is to compare oxidative stress markers and the immunologic characteristics of HIV-infected and non-HIV subjects during a bout of moderate aerobic exercise followed by resistance exercises
Eligibility Criteria
Inclusion Criteria
- HIV Group: without contraindications for exercise training; to highly active antiretroviral therapy (HAART) for at least 6 months before enrollment; be classified as low level of physical activity by international physical activity questionnaire (IPAQ) and did not use antioxidant supplements.
- Control Group: negative result for HIV-1 test and the other criteria described above
Exclusion Criteria
- Subjects with previous history of cardiovascular and neurological disease, diabetes, dyslipidemia, tobacco using, physical disability and pregnant women were excluded from the study.
Data sourced from ClinicalTrials.gov (NCT00950937). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.