N/A Completed N=53

Gastroesophageal Reflux Disease (GERD) Before and After Gastric Bypass

Gastroesophageal Reflux Disease · Morbid Obesity

Source: ClinicalTrials.gov NCT00951093 ↗

Enrolled (actual)

Serious AEs

—

Results posted

Apr 2014

Primary outcomePrimary: Number of Participants Presenting Reflux Symptoms — 31; 8; 5 participants — p=<0.001

Summary

The hypothesis of this study was that gastric bypass (GBP) ameliorates gastroesophageal reflux disease (GERD) in morbidly obese patients.

Outcome Measures

Outcome	Result	p-value
PRIMARY Number of Participants Presenting Reflux Symptoms	31; 8; 5	<0.001 sig
PRIMARY Number of Participants With Esophageal Injury	24; 17; 10	0.002 sig
PRIMARY Number of Participants With Gastroesophageal Reflux Disease (GERD)	34; 21; 12	< 0.001 sig
PRIMARY Total Esophageal Acid Exposure at 24h pH Monitoring	5.1; 1.2; 0.1	< 0.020 sig
PRIMARY Esophageal Acid Exposure at 24h pH Monitoring in Upright Position	5.9; 0.8; 0.1	< 0.001 sig
PRIMARY Esophageal Acid Exposure at 24h pH Monitoring in Supine Position	1.8; 0.5; 0.0	0.001 sig
PRIMARY Number of Participants With Increased Acid Exposure	31; 16; 9	< 0.001 sig

Eligibility Criteria

Inclusion Criteria

Morbid obesity
Acceptance to undergo open gastric bypass

Exclusion Criteria

Prior gastroesophageal surgery
Achalasia

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00951093). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.