Phase 3 Completed N=104 Randomized Single-blind Treatment

Comparison of Two Methods of Securing Skin Grafts Using Negative Pressure Wound Therapy: Vacuum Assisted Closure (VAC) and Gauze Suction (GSUC)

wound healing

Source: ClinicalTrials.gov NCT00952120 ↗

Enrolled (actual)

104

Serious AEs

0.0%

Results posted

Sep 2015

Primary outcomePrimary: Percentage of Wounds With Complete Skin Graft Take — 80; 78 percentage of wounds — p=0.80

Summary

The purpose of this study is to compare how well two methods (VAC and G-SUC) of securing skin grafts using negative pressure wound therapy work. Negative pressure wound therapy is a commonly used method of applying suction on wounds to remove fluid from wound and to promote healing. The VAC system is widely used and consists of a foam dressing and a portable computerized suction pump. The G-SUC method uses commonly available dressing supplies attached to vacuum (suction) pump located on the wall above a hospital bed. The investigators have frequently used both methods over the past 10 years and have not observed any specific negative side effects of either.

Outcome Measures

Outcome	Result	p-value
PRIMARY Percentage of Wounds With Complete Skin Graft Take	80; 78	0.80
SECONDARY Percentage of Wounds With Total Skin Graft Loss	3.8; 1.3	—

Eligibility Criteria

Inclusion Criteria

Adult patients of any sex, hospitalized at the University of Chicago Medical Center, requiring split thickness skin autografts with wounds that are amenable to placement of an occlusive dressing for negative pressure therapy will be eligible to participate in the study

Exclusion Criteria

Pregnant women, children under 18 years of age and other patients who are "vulnerable" as defined by the Institutional Review Board will not be eligible for the study

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Data sourced from ClinicalTrials.gov (NCT00952120). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.