Phase 2
Completed N=142
Efficacy of Antidepressants in Chronic Back Pain
Back Pain
Source: ClinicalTrials.gov NCT00964886 ↗
Enrolled (actual)
142
Serious AEs
1.4%
Results posted
Nov 2016
Primary outcomePrimary: Intent-toTreat Analysis of Descriptor Differential Scale (DDS) of Pain Intensity — 8.3; 8.1 units on a scale — p=0.7
Summary
This 12 week placebo controlled clinical trial tests the individual and combined effects of an antidepressant medication and cognitive behavioral therapy for chronic back pain.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Intent-toTreat Analysis of Descriptor Differential Scale (DDS) of Pain Intensity |
8.0; 8.4 | 0.6 |
| SECONDARY Roland and Morris Disability Questionnaire |
8.7; 8.9 | 0.8 |
Eligibility Criteria
Inclusion Criteria
- Chronic back pain (daily pain for > 6 months)
Exclusion Criteria
- Major medical conditions which might contraindicate antidepressant treatment
Data sourced from ClinicalTrials.gov (NCT00964886). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.