Phase 3
Completed N=1,516
Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation
Source: ClinicalTrials.gov NCT00970489 ↗Enrolled (actual)
1,516
Serious AEs
18.7%
Results posted
Apr 2017
Primary outcomePrimary: Any First Post-op Atrial Fibrillation or Flutter (AF) — 233; 227 Participants
◆ Published Evidence
Highly cited
231citations · ~17 / year
Fish oil and postoperative atrial fibrillation: the Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) randomized trial.
Summary
This is a large multi-center study to examine whether peri-operative intake of n-3 polyunsaturated fatty acids (PUFA) will reduce the occurrence of post-operative atrial fibrillation or flutter (AF) in patients undergoing cardiac surgery (CS).
Linked Publications (5)
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Fish oil and postoperative atrial fibrillation: the Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) randomized trial.
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Fish Oil and Perioperative Bleeding.
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Oxidative Stress Biomarkers and Incidence of Postoperative Atrial Fibrillation in the Omega-3 Fatty Acids for Prevention of Postoperative Atrial Fibrillation (OPERA) Trial.
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Plasma phospholipid omega-3 fatty acids and incidence of postoperative atrial fibrillation in the OPERA trial.
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Fish Oil Supplementation Does Not Affect Cognitive Outcomes in Cardiac Surgery Patients in the Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation (OPERA) Trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Any First Post-op Atrial Fibrillation or Flutter (AF) |
233; 227 | — |
| SECONDARY Post-op Af |
231; 224; 220; 217 | — |
| SECONDARY Other Arrhythmias |
6; 11; 9; 5 | — |
| SECONDARY Other Endpoints |
20; 13; 15; 8 | — |
Eligibility Criteria
Inclusion Criteria
- Age 18 years or over
- Scheduled for CS on the following day or later, including coronary artery bypass, valve surgery, any other open cardiac surgery (i.e., that includes opening of the pericardium), or any combination.
- Sinus rhythm on current ECG (sinus bradycardia, sinus tachycardia, and ectopy are acceptable).
Exclusion Criteria
- Regular use (3 or more days/week) of fish oil within the past 4 weeks.
- Known allergy or intolerance to fish oil or corn oil.
- Currently pregnant.
- Unable to provide informed written consent.
- Current or planned cardiac transplant or LVAD
Data sourced from ClinicalTrials.gov (NCT00970489) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.