Phase 4
Completed N=42
The Effect of Ketamine on Interleukin-6 Synthesis in Hepatic Resections Requiring Temporary Porto-arterial Occlusion
Source: ClinicalTrials.gov NCT00978757 ↗Enrolled (actual)
42
Serious AEs
0.0%
Results posted
Jan 2010
Primary outcomePrimary: The Effect of Ketamine on Interleukin 6 (IL-6) Synthesis in Hepatic Resections Requiring Temporary Porto-arterial Occlusion (Pringle Maneuver) — 116.14; 151.29 pg/ml — p=0.05
Summary
The purpose of this study is to determine whether ketamine is effective to inhibit interleukin 6 synthesis in hepatic resections requiring temporary porto-arterial occlusion.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY The Effect of Ketamine on Interleukin 6 (IL-6) Synthesis in Hepatic Resections Requiring Temporary Porto-arterial Occlusion (Pringle Maneuver) |
116.14; 151.29 | 0.05 |
Eligibility Criteria
Inclusion Criteria
- Age: 21 or older
- Planned liver resection with Pringle maneuver lasting 30-60 minutes
Exclusion Criteria
- Chronic illness requiring corticosteroids
- Cirrhosis
- Hemodynamic instability prior to surgery
- Diabetes
- Sepsis
- Surgical interventions or chemotherapy treatments within the past 30 days
- Pregnancy
- Illnesses that could potentially affect the hepatic circulation
- Arterial hypertension
- Ocular hypertension
- Allergy to ketamine
- Preoperative portal embolization
- Radiofrequency ablation
- Patients requiring emergency surgeries
Data sourced from ClinicalTrials.gov (NCT00978757). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.