N/A Completed N=33 Randomized Double-blind Treatment

The Effect of Grape Seed Extract on Blood Pressure in People With Pre-Hypertension

Hypertension

Source: ClinicalTrials.gov NCT00979732 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Feb 2021

Primary outcomePrimary: Systolic Blood Pressure — 118; 127 mmHg

Summary

In this research study, the investigators are interested in learning how extracts from grape seeds can help those individuals with high blood pressure. The investigators also hope to learn how grape seed extract effects your blood and cell functions. The grape seed extract the investigators will use in the study will be provided either in a beverage or a capsule form and is currently available on the market. This study is also using a placebo; therefore the treatment subjects receive may or may not contain the grape seed extract. The purpose of this study is to determine if the grape seed extract (GSE) will lower blood pressure in people with slightly high blood pressure (Pre-Hypertension).

Outcome Measures

Outcome	Result	p-value
PRIMARY Systolic Blood Pressure	118; 127	—
SECONDARY Plasma Insulin Level Over 6 Weeks	17.8; 20.9	—

Eligibility Criteria

Inclusion Criteria

male and female
pre-hypertensive
systolic blood pressure (mmHg) 120 - 139 or
diastolic blood pressure (mmHg) 80 -89
no clinical evidence of cardiovascular, respiratory, renal, gastrointestinal or hepatic disease

Exclusion Criteria

pregnant and or lactating
taking over the counter antioxidant supplements
taking prescription medications that may interfere with study procedures or endpoints
unusual dietary habits
actively trying to lose or gain weight
addicted to drugs and/or alcohol
medically documented psychiatric or neurological disturbances
smoker (past smoker may be allowed if cessation is > 2 years)

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00979732). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.