N/A
N=67
Markers of Liver Apoptosis After Anesthesia With Sevoflurane or Propofol
Liver Dysfunction
Bottom Line
View on ClinicalTrials.gov: NCT01000337 ↗Enrolled (actual)
67
Serious AEs
0.0%
Results posted
Sep 2012
Primary outcome: Primary: Changes in the M30 and M65 Markers Related to the Anesthesia Type — 237.27; 279.97; 427.33; 470.30 U/L
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Sevoflurane (Drug); Propofol (Drug)
- Age
- Adult, Older Adult · 30+ yrs
- Sex
- Female
- Sponsor
- University of Athens
- Primary completion
- Nov 2011
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Changes in the M30 and M65 Markers Related to the Anesthesia Type |
237.27; 279.97; 427.33; 470.30; 241.83; 299.97 | — |
| SECONDARY Transaminases |
— | — |
Summary
Anesthesia may affect the function of vital organs. Liver is one of them. The investigator's hypothesis is that intravenous or inhalation anesthesia does not impair liver function as assessed by more elegant tests like markers indicating liver apoptosis. In the present randomized prospective trial female patients scheduled for mastectomy or thyroidectomy will receive inhalation or total intravenous anesthesia and markers for liver dysfunction will be determined.
Eligibility Criteria
Inclusion Criteria
- Female patients aged between 30 and 65 years old scheduled for thyroidectomy or breast surgery for cancer
Exclusion Criteria
- Drug intake which may affect liver function
- Severe cardiovascular or respiratory disease
- Hepatic or renal dysfunction
- Pregnancy
- Alcohol and drug abuse
- Body Mass Index (BMI) > 35
Data sourced from ClinicalTrials.gov (NCT01000337). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.