N/A
Completed N=24
The Cognitive and Cerebral Blood Flow Effects of Resveratrol
Cognitive and Cerebral Blood Flow Effects of Resveratrol
Source: ClinicalTrials.gov NCT01010009 ↗
Enrolled (actual)
24
Serious AEs
0.0%
Results posted
Apr 2011
Primary outcomePrimary: Modulation of Levels of Total Haemoglobin — 1.9; 2.4; 1.2 µmol/L — p=>0.05
Summary
Research shows that resveratrol is able to induce vasodilation (and therefore blood flow) by interacting with nitric oxide (NO). Research also shows that acute administration of metabolic substrates, like oxygen and glucose, can enhance aspects of cognitive performance in young, healthy humans. The aim of this investigation was to determine if the consumption of resveratrol could modulate cerebral blood flow and if this in turn could influence cognitive performance by increasing access to blood borne metabolic fuel. Results showed that compared to placebo, after consuming 500mg pure trans-resveratrol, levels of total haemoglobin were significantly higher in the frontal cortex of young, healthy participants during cognitive task completion. Cognitive performance was not effected.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Modulation of Levels of Total Haemoglobin |
1.9; 2.4; 1.2 | >0.05 |
| PRIMARY Modulation of Deoxygenated Levels of Haemoglobin |
0.4; 0.2; -0.2 | <0.05 sig |
| SECONDARY Number of Participants With Significant Modulation of Cognitive Performance |
0; 0; 0 | >0.05 |
Eligibility Criteria
Inclusion Criteria
- Male/female,
- Healthy
- Age 18-35 years old
- Non smoker
- Proficient in English
- Not taking any herbal or prescription medications
- Not pregnant
- Does not drink more than 6 cups of coffee per day
Exclusion Criteria
- Suffered a head injury, neurological disorder or neuro-developmental disorder
- Food allergies/intolerances
Data sourced from ClinicalTrials.gov (NCT01010009). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.