Phase 2
N=64
A Study for Participants With Small-Cell Lung Cancer
Small Cell Lung Cancer
Bottom Line
View on ClinicalTrials.gov: NCT01025284 ↗Enrolled (actual)
64
Serious AEs
37.5%
Results posted
Dec 2017
Primary outcome: Primary: Part A: Percentage of Participants Achieving an Overall Response (Overall Response Rate) — 2.6 percentage of participants
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- LY2523355 (Drug); Granulocyte colony-stimulating factor (G-CSF) (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Eli Lilly and Company
- Primary completion
- Jul 2012
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Part A: Percentage of Participants Achieving an Overall Response (Overall Response Rate) |
2.6 | — |
| PRIMARY Part B: Percentage of Participants Achieving a Best Response (Clinical Benefit Rate) |
26.9 | — |
| SECONDARY Part A: Progression-Free Survival |
5.3 | — |
| SECONDARY Part B: Progression-Free Survival |
6.1 | — |
| SECONDARY Part A: Percentage of Participants Achieving a Best Response (Clinical Benefit Rate) |
23.7 | — |
| SECONDARY Part B: Percentage of Participants Achieving an Overall Response (Overall Response Rate) |
— | — |
| SECONDARY Part A: Pharmacokinetics - Maximum Observed Plasma Concentration (Cmax) of LY2523355 and Its Metabolite (LSN2546307) |
146; 157; 100; 7.17; 6.29; 6.11 | — |
| SECONDARY Part B: Pharmacokinetics - Maximum Observed Plasma Concentration (Cmax) of LY2523355 |
128; 258 | — |
| SECONDARY Part A: Pharmacokinetics - Area Under the Plasma Concentration Versus Time Curve of LY2523355 From Time Zero to Infinity [AUC(0-∞)] |
— | — |
| SECONDARY Part B: Pharmacokinetics - Area Under the Plasma Concentration Versus Time Curve of LY2523355 From Time Zero to Infinity [AUC(0-∞)] |
639; 1220 | — |
| SECONDARY Total Lung Cancer Symptom Scale (LCSS) and Average Symptom Burden Index (ASBI) |
28.24; 42.61; 26.76; 36.41 | — |
Summary
Part A: This study evaluates an experimental treatment in participants with extensive-disease in small-cell lung cancer.
Part B: This study evaluates an experimental treatment in participants with extensive-disease in small-cell lung cancer.
Eligibility Criteria
Inclusion Criteria
- Have histological or cytological evidence of extensive-disease small-cell lung cancer
- Have the presence of measurable disease as defined by the Response Evaluation Criteria in Solid Tumors (RECIST 1.1)
- Have received at least 1 prior chemotherapy regimen with agents known to provide clinical benefit for small-cell lung cancer and be, in the opinion of the investigator, an appropriate candidate for experimental therapy
- Have discontinued all previous therapies for cancer, including chemotherapy, biologic therapy, hormone therapy, or radiotherapy. Participants must have recovered from the acute effects of therapy (except alopecia and fatigue) before study enrollment
- Part A: Have a performance status of 0 to 2 on the Eastern Cooperative Oncology Group scale
- Part B: Have a performance status of 0 to 1 on the Eastern Cooperative Oncology Group scale
Exclusion Criteria
- Have received treatment within 28 days of the first dose of LY2523355 with a drug that has not received regulatory approval for any indication
- Have a mixed histological diagnosis of small-cell lung cancer and non-small-cell lung cancer
- Have serious preexisting medical conditions that, in the opinion of the investigator, would preclude participation in this study
- Part A: Have symptomatic, untreated, or uncontrolled central nervous system (CNS) metastases. Participants with treated CNS metastases are eligible provided their disease is radiographically stable, asymptomatic, and corticosteroid use has been discontinued for at least 2 weeks prior to the first dose of study drug. Screening of asymptomatic participants without history of CNS metastases is not required
- Part B: Have symptomatic, untreated, or uncontrolled CNS metastases or a history of CNS metastases. Participants who have received prophylactic radiation are not excluded. Screening of asymptomatic participants without history of CNS metastases is not required
Data sourced from ClinicalTrials.gov (NCT01025284). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.