Phase 2 N=206 Randomized Quadruple-blind Treatment

Comparison of Intravenous Cefazolin Plus Oral Probenecid With Oral Cephalexin for the Treatment of Cellulitis

Cellulitis

Bottom Line

View on ClinicalTrials.gov: NCT01029782 ↗

Enrolled (actual)

206

Serious AEs

0.0%

Results posted

Aug 2018

Primary outcome: Primary: The Number of Patients Failing Therapy After 72 Hours of Antibiotic Treatment With Oral Cephalexin or Intravenous Cefazolin Plus Oral Probenecid. — 6; 4 Participants

Study Design & Population

Study type: Interventional
Phase: Phase 2
Interventions: IV cefazolin plus oral probenecid and placebo cephalexin (Drug); Oral cephalexin and saline IV plus probenecid placebo (Drug)
Age: Adult, Older Adult · 19+ yrs
Sex: All
Sponsor: Kelowna General Hospital
Primary completion: Oct 2014

Outcome Measures

Outcome	Result	p-value
PRIMARY The Number of Patients Failing Therapy After 72 Hours of Antibiotic Treatment With Oral Cephalexin or Intravenous Cefazolin Plus Oral Probenecid.	6; 4	—

Summary

The purpose of this study is to determine whether oral cephalexin is equivalent to intravenous cefazolin plus oral probenecid for the treatment of uncomplicated skin and soft tissue infections in patients that present to the emergency department.

Eligibility Criteria

Inclusion Criteria

Patients presenting to the emergency department with a presumed diagnosis of mild to moderate skin and soft tissue infection
Deemed well enough to be treated as an outpatient
19 years of age or older

Exclusion Criteria

known allergy to study drugs
known chronic kidney disease with a creatinine clearance 30 kg/m2)

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01029782). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.