Phase 2
N=332
Study To Assess FRacTure Healing With SclerosTin Antibody - Hip
Fracture Healing
Bottom Line
View on ClinicalTrials.gov: NCT01081678 ↗Enrolled (actual)
332
Serious AEs
23.1%
Results posted
May 2019
Primary outcome: Primary: Timed-Up-and-Go (TUG) Over Week 6 Through Week 20 — 54.1; 41.0; 47.2; 53.3 seconds — p=0.1983
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- Placebo (Drug); Romosozumab (Drug)
- Age
- Adult, Older Adult · 55+ yrs
- Sex
- All
- Sponsor
- Amgen
- Primary completion
- Jun 2012
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Timed-Up-and-Go (TUG) Over Week 6 Through Week 20 |
54.1; 41.0; 47.2; 53.3; 29.8; 27.6 | 0.1983 |
| SECONDARY Timed-Up-and-Go (TUG) at Each Visit |
132.3; 119.3; 121.7; 129.8; 92.4; 69.5 | — |
| SECONDARY Time to Radiographic Healing |
16.4; 16.9; 16.6; 16.9 | — |
| SECONDARY Radiographic Union Scale for Hip (RUSH) Score At Each Visit |
12.1; 12.7; 12.1; 12.0; 18.1; 18.0 | — |
| SECONDARY Harris Hip Score At Each Visit |
46.6; 47.7; 47.3; 46.5; 58.6; 62.5 | — |
| SECONDARY Hip Pain Score at Each Visit |
34.3; 33.1; 40.3; 43.0; 26.3; 19.5 | — |
Summary
This is an international, multi-center study to determine the efficacy, safety, and tolerability of romosozumab (AMG 785) in adults with a fresh unilateral hip fracture, status post surgical fixation.
Eligibility Criteria
Inclusion Criteria
- Males and females, age 55 to 95 years
- fresh unilateral low energy intertrochanteric or femoral neck fracture as the primary injury, confirmed by X-ray and in the opinion of the treating surgeon amenable to repair by internal fixation
- internal fixation of the fracture with devices approved by local regulatory agency, performed no later than 7 days after injury for intertrochanteric or undisplaced femoral neck fractures and no later than 2 days after injury for displaced femoral neck fractures
- intertrochanteric fracture: sliding hip screw or IM nail
- femoral neck fracture: sliding hip screw or at least 3 cancellous screws
Exclusion Criteria
- severe symptomatic osteoarthritis of the lower extremity
- inability to independently rise from armchair or walk 200 meters before hip fracture
- presence of concomitant injuries such as rib fractures, wrist fractures, or acute symptomatic vertebral fractures which severely impair the ability to rise from a chair
- associated extremity injuries including ipsilateral or contralateral fractures of the foot, tibia or fibula, wrist, humerus, femoral shaft, femoral head or hip dislocation, that may delay weight-bearing beyond one week after surgery
- head-injury, as defined by Glasgow Coma Scale 16
- pathological fracture or history of metabolic or bone disease (except osteoporosis) that may interfere with the interpretation of the results, such as Paget's disease, rheumatoid arthritis, osteomalacia, osteopetrosis, ankylosing spondylitis, Cushing's disease, hyperprolactinemia
- history of symptomatic spinal stenosis that has not been surgically corrected. If surgically corrected, the subject must be asymptomatic to be eligible for the study.
- history of facial nerve paralysis
- malignancy (except fully resected cutaneous basal cell or squamous cell carcinoma, cervical carcinoma in situ) within the last 5 years
- history of solid organ or bone marrow transplants
- evidence of elevated transaminases (≥ 2.0 x upper limits of normal) or significantly impaired renal function (creatinine clearance of ≤ 30 mL/min)
- evidence of current hypercalcemia or hypocalcemia (outside of 1.1 x the normal range)
- bone morphogenic proteins (BMP)-2 or BMP-7 at the time of definitive fracture fixation
Data sourced from ClinicalTrials.gov (NCT01081678). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.