N/A
Completed N=170
Gustin Gene Polymorphism and 6-n-propylthiouracil (PROP) Taste
Dysgeusia
Source: ClinicalTrials.gov NCT01097915 ↗
Enrolled (actual)
170
Serious AEs
0.0%
Results posted
Dec 2016
Primary outcomePrimary: Association Between Gustin Gene Polymorphism and PROP Sensitivity — 85.19; 50.99; 25.00; 14.81 percentage of participants — p=<0.01
Summary
The investigators evaluate the possible association of PROP taste with gustin gene polymorphism rs2274333 (A/G), salivary zinc ion concentration and BMI. In addition, it has also been evaluated PROP taste sensitivity by recording monophasic potentials from the tongue.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Association Between Gustin Gene Polymorphism and PROP Sensitivity |
85.19; 50.99; 25.00; 14.81; 35.71; 20 | <0.01 sig |
| SECONDARY Association Between PROP Sensitivity and Saliva Zinc Ion Concentration |
57.3; 89.5; 149.64 | <0.004 sig |
| SECONDARY Association Between PROP Sensitivity and BMI |
20.3; 20.76; 22.58 | <0.048 sig |
| SECONDARY Electrophysiological Recordings From the Tongue for the Objective Evaluation of Individual Variations of 6-n-propylthiouracil (PROP) Sensitivity |
97,08867; 75,42000; 48,48231 | < 0.00001 sig |
| SECONDARY Association Between PROP Sensitivity and Fungiform Papilla Density |
51.66; 33.49; 18.53 | < 0.00001 sig |
| SECONDARY Taste Perception of Sweet, Sour, Salty, Bitter and Umami and Changes Due to L-Arginine Supplementation, as a Functin of Genetic Ability to Taste PROP. |
18; 2; 40; 20; 6; 42 | < 0.00001 sig |
Eligibility Criteria
Inclusion Criteria
- no variation of body weight > 5 kg over the last 3 mo BMI within 20-25 Age between 20-30
Exclusion Criteria
- gustatory impairment following a prescribed diet or using medications that might interfere with taste perception food allergies smokers
Data sourced from ClinicalTrials.gov (NCT01097915). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.