Phase 3 N=33 Randomized Quadruple-blind Prevention

Vitamin C for Prophylaxis of Post-operative Atrial Fibrillation in On-pump Cardiac Surgery Procedures

Atrial Fibrillation

Bottom Line

View on ClinicalTrials.gov: NCT01107730 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

May 2015

Primary outcome: Primary: Incidence of Postoperative Atrial Fibrillation — 5; 4; 5 participants

Study Design & Population

Study type: Interventional
Phase: Phase 3
Interventions: Vitamin C (Drug); L-Carnitine (Drug); Placebo (Drug)
Age: Pediatric, Adult, Older Adult · 15+ yrs
Sex: All
Sponsor: Attikon Hospital
Primary completion: Apr 2015

Outcome Measures

Outcome	Result	p-value
PRIMARY Incidence of Postoperative Atrial Fibrillation	5; 4; 5	—

Summary

The purpose of this study is to determine whether vitamin C is effective in the prophylaxis of post-operative atrial fibrillation in on-pump cardiac surgery

Eligibility Criteria

Inclusion Criteria

Patients undergoing on-pump cardiac surgery

Exclusion Criteria

Off-pump cardiac surgery procedure
AF before the procedure
Recent infection and/or infectious endocarditis
Presence of neoplasia
Chronic renal failure with creatinine>2.3 mg/dl
Hepatic failure
Autoimmune disease and/or disease that brings about a systematic inflammatory response
Thyroid disease
Systematic use of supplements that contain vitC or carnitine
The use of NSAIDs other than aspirin for a time period up to one month before the procedure

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01107730). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.