Phase 2
N=66
Biobehavioral Effects of Topiramate on Cannabis-Related Outcomes in Adolescents
Cannabis Abuse · Cannabis Dependence
Bottom Line
View on ClinicalTrials.gov: NCT01110434 ↗Enrolled (actual)
66
Serious AEs
0.0%
Results posted
Sep 2020
Primary outcome: Primary: Cannabis Use — 55.89; 63.10 Percentage of use days
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- Topiramate (Drug); Placebo (Drug)
- Age
- Pediatric, Adult · 15+ yrs
- Sex
- All
- Sponsor
- Brown University
- Primary completion
- May 2012
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Cannabis Use |
55.89; 63.10 | — |
| SECONDARY Quantity of Cannabis Use |
1.87; 2.85 | — |
| SECONDARY Amount of Cannabis Use Per Use Day |
0.46; 0.60 | — |
Summary
Cannabis use is a significant public health concern that disproportionately affect youth. Although promising psychosocial interventions are being developed, most youth do not benefit from these interventions alone. Given the clinical demand for effective treatments, the National Institute on Drug Abuse (NIDA) identified the critical need for data on the tolerability and potential efficacy of medications in adolescents. The purpose of this two-year study is to test if and how topiramate, a medication under intense study for treating several drugs of abuse, reduces cannabis use among teenagers. To this end, the investigators will randomize 56 nontreatment-seeking regular cannabis users (15 or 20 years old) to receive topiramate or placebo for 6 weeks. Youth will monitor their cannabis use for the 6-week period using handheld electronic diaries and complete assessments of reactivity to cannabis-related cues.
Eligibility Criteria
Inclusion Criteria
- 15 to 20 years old (inclusive)
- Non-treatment seeking for cannabis abuse or dependence
- Able to read English, understand their rights as provided by the informed consent process, and be willing to sign an informed consent form to participant in the study
- If younger than 18 years old, informed consent from a parent or legal guardian is required
- Used cannabis at least 2 days per week during the past 30 days
Exclusion Criteria
- Treatment seeking or a recent history of treatment for cannabis abuse or dependence
- Endorses a current commitment to stop using cannabis
- Clinically significant physical abnormalities as indicated by physical exam, hematological assessment, bilirubin concentration or urinalysis
- History of renal impairment, renal stones, seizures, or unstable hypertension
- Underweight (i.e., less than the 5th percentile) or overweight (equal to or greater than the 95th percentile), as determined by the Body Mass Index
- Positive urine toxicology screen for narcotics, amphetamines, or sedative hypnotics or self-reported drug use, other than cannabis, alcohol or nicotine, in the past 30 days
- Pregnant, nursing, or refusal to use reliable barrier method of birth control (e.g., condom), if female
- Took a psychotropic medication in the past 30 days
- Taking medications with a potential effect on cannabis use or a carbonic anhydrase inhibitor
- Suicidal
- A current DSM-IV-TR Axis I diagnosis other than attention- deficit/hyperactivity disorder or a disruptive behavior disorder
- A current substance use disorder other than a cannabis, alcohol, and nicotine use disorders
- Significant alcohol withdrawal symptoms
- Known sensitivity to topiramate
Data sourced from ClinicalTrials.gov (NCT01110434). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.