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N/A N=396 Randomized Double-blind Prevention

Achieving Medication Safety During Acute Kidney Injury

Kidney Failure, Acute

Enrolled (actual)
396
Serious AEs
Results posted
Feb 2012
Primary outcome: Primary: Adverse Drug Events or Potential Adverse Drug Events — 99; 104 Patient-Medication Pairs

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
Pharmacy Dashboard Review and Intervention (Other)
Age
Adult, Older Adult · 18+ yrs
Sex
All
Sponsor
Vanderbilt University
Primary completion
Aug 2010

Outcome Measures

OutcomeResultp-value
PRIMARY
Adverse Drug Events or Potential Adverse Drug Events
99; 104
SECONDARY
Time to Provider Response
23.7; 27.31; 42.37; 43.83

Summary

The utilization of clinical decision support (CDS) is increasing among healthcare facilities which have implemented computerized physician order entry or electronic medical records. Formal prospective evaluation of CDS implementations occurs rarely, and misuse or flaws in system design are often unrecognized. Retrospective review can identify failures but is too late to make critical corrections or initiate redesign efforts. A real-time surveillance dashboard for high-alert medications integrates externalized CDS interactions with relevant medication ordering, administration, and therapeutic monitoring data. The surveillance view of the dashboard displays all currently admitted, eligible patients and provides brief demographics with triggering order, laboratory, and CDS failure data to allow prioritization of high-risk scenarios. The patient detail view displays a detailed timeline of orders, order administrations, laboratory values, and CDS interactions for an individual patient and allows users to understand provider actions and patient condition changes occurring in conjunction with CDS failures. Clinical pharmacists' use of the dashboard for patient monitoring and intervention aims to increase the rate and timeliness of intercepted medication errors compared to CPOE-based CDS in the setting of acute kidney injury, which affects patients at various points across all hospital units and services and has numerous opportunities for intervention.

Eligibility Criteria

Inclusion Criteria

  • 0.5 mg/dl increase or decrease in serum creatinine within 48 hours
  • Active, recurring order for targeted renally cleared or nephrotoxic medication

Exclusion Criteria

  • Chronic dialysis
  • Transplant patients
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01134900). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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