Phase 2 Completed N=165 Randomized Prevention

Efficacy of Proton Pump Inhibitor in Prevention of Clopidogrel-related Peptic Ulcer

Peptic Ulcer

Source: ClinicalTrials.gov NCT01138969 ↗

Enrolled (actual)

165

Serious AEs

2.4%

Results posted

Feb 2013

Primary outcomePrimary: Recurrent Peptic Ulcer — 1; 9 participants

Summary

Proton Pump Inhibitors (PPI) can prevent the recurrence of peptic ulcer in clopidogrel users.

Outcome Measures

Outcome	Result	p-value
PRIMARY Recurrent Peptic Ulcer	1; 9	—
SECONDARY Peptic Ulcer Bleeding	0; 1	—

Eligibility Criteria

Inclusion Criteria

We plan to enroll 300 clopidogrel users without baseline gastroduodenal ulcer at initial endoscopy. The patients will be randomly assigned to receive either (1) esomeprazole (20 mg qd) plus clopidogrel or (2) clopidogrel treatment alone for 6 months.

Exclusion Criteria

1.serious disease 2.refuse informed consent

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Data sourced from ClinicalTrials.gov (NCT01138969). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.