Study of MK-2206 in Patients With Metastatic Neuroendocrine Tumors (NET)

Inclusion Criteria

• Patients with histologically or cytologically confirmed moderately to well differentiated metastatic or unresectable carcinoid or islet cell tumors.
• Patient has at least one measurable lesion greater than or equal to 20 mm on CT or MRI imaging.
• Patients who are on therapy with a somatostatin analog are eligible for entry but must be on a stable dose for at least 3 months with no evidence of tumor shrinkage during that time period.
• Patient ≥18 years of age on the day of signing informed consent.
• Patient has performance status 0-1 on the ECOG Performance Scale.
• Patient has adequate organ function as indicated by the following laboratory values:
• Absolute Neutrophil Count (ANC)≥1,500/mcL
• Platelets ≥100,000/mcL
• Hemoglobin ≥9 g/dL
• Serum Creatinine ≤2 times the upper limit of normal (ULN)/ OR calculated CrCl ≥60 mL/min (patients with creatinine levels ≥2 times the ULN only). Patient may not be on dialysis
• Serum total bilirubin ≤1.5 times the ULN
• AST (SGOT) and ALT (SGPT) ≤5 times the ULN
• HgbA1c ≤ 8%
• Fasting Glucose ≤120 mg/dl
• Creatinine clearance should be calculated by the Cockcroft-Gault method.Fasting is defined as at least 4 hours without oral intake.
• Patient has voluntarily agreed to participate by giving written informed consent.
• Previous local therapy (e.g. chemoembolization or bland embolization) is allowed if completed > 6 weeks or 5X half-life prior to study entry. For patients who received local therapy prior to study entry, there must be either documented growth of measurable disease within the embolization field or outside of the embolization field, or both, prior to study entry if the area of the embolization field was the only site of measurable disease.
• Previous chemotherapy, radiotherapy, and/or biologic therapy, including investigational agents, is/are allowed if completed > 4 weeks prior to study entry (>6 weeks if last regimen contained bevacizumab, BCNU or mitomycin C, and > 6 weeks from last dose of radiation therapy or radiopharmaceutical.
• Patients must not have disease that is currently amenable to curative surgery. Prior surgery is allowed no less than 6 weeks prior to study entry.
• Patients with diabetes mellitus are eligible for study entry but must have controlled diabetes as defined by hemoglobin A1c 450 msec (Bazett's formula)
• Patient with evidence of clinically significant bradycardia (HR 8%)
• Patient has a history or current evidence of any condition, therapy, or lab abnormality that might confound the results of the study, interfere with the patient's participation for the full duration of the study, or is not in the best interest of the patient to participate, in the opinion of the treating Investigator.
• Patient has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial.
• Patient is, at the time of signing informed consent, a regular user (including -recreational use‖) of any illicit drugs or had a recent history (within the last year) of drug or alcohol abuse.
• Patient is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the study.
• Patient is known to be Human Immunodeficiency Virus (HIV)-positive
• Patient has known history of Hepatitis C or active Hepatitis A or B.
• Patient has symptomatic ascites or pleural effusion. A patient who is clinically stable following treatment for these conditions is eligible.
• Patient has prior treatment with an mTOR inhibitor such as afinitor, sirolimus, or temsirolimus.