Phase 2
Completed N=60
An Extension Protocol for Subjects Who Were Previously Enrolled in Other Tivantinib (ARQ 197) Protocols
Source: ClinicalTrials.gov NCT01178411 ↗Enrolled (actual)
60
Serious AEs
31.7%
Results posted
Feb 2021
Primary outcomePrimary: Extent of Exposure to ARQ 197 in Participants Benefiting From Prior ARQ 197 Therapy — 125 Days
Summary
This is an extension study that will allow participants to continue to receive study therapy when the original studies into which they were enrolled have reached their designated end-dates. This extension study is designed to further evaluate the safety and tolerability of tivantinib (ARQ 197) monotherapy or in combination with other drug(s) when given to participants who tolerated previous treatment well and may benefit from the continuing treatment.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Extent of Exposure to ARQ 197 in Participants Benefiting From Prior ARQ 197 Therapy |
125 | — |
| SECONDARY Number of Participants With ≥1 Treatment-emergent Adverse Event (TEAE) |
56 | — |
| SECONDARY Number of Participants Discontinuing Treatment Due to an AE |
6 | — |
Eligibility Criteria
Inclusion Criteria
- Signed written informed consent to participate in clinical study of tivantinib
- Male or female participants of the age defined in the original protocol they were enrolled.
- Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≤3 (or ≤2 for tivantinib-naive participants)
- Adequate bone marrow function:
- Absolute neutrophil count (ANC) ≥1.5 x 10^9/L
- Hemoglobin ≥8.0 g/dL (or ≥ 9.0 g/dL for tivantinib-naïve participants)
- Enrollment within 14 days of the completion of End of Treatment Visit of the original study
- Participants, who participated in previous ARQ 197 studies that have reached their designated end-dates, who did not meet discontinuation criteria in their original study, and who may, in the opinion of the Investigator and the Sponsor, benefit from treatment
- Women of childbearing potential must have a negative pregnancy test performed within 14 days of the start of study drug. Both men and women enrolled in this study must agree to use adequate birth control measures while on study
Exclusion Criteria
- Known or suspected allergy to ARQ 197
- Substance abuse, medical, psychological or social conditions that may interfere with the participant's participation in the study or evaluation of the study results
- Any condition that is unstable or which could jeopardize the safety of the participant and his/her compliance in the study
- A serious uncontrolled medical disorder/condition that in the opinion of the Investigator would impair the ability of the participant to receive protocol therapy
- Requirement to receive other concurrent chemotherapy (excluding combination therapy defined in original protocol), immunotherapy, radiotherapy, or any other investigational drug while on study. Palliative radiotherapy is allowed provided that:
- in the opinion of the Investigator, the participant does not have progressive disease
- the radiation field does not encompass a target lesion
- no more than 10% of the participant's bone marrow is irradiated
Data sourced from ClinicalTrials.gov (NCT01178411). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.