Phase 4
Completed N=40
Anti Propionibacterium(P.) Acnes Activity of Epiduo® Gel Compared to Benzoyl Peroxide (BPO) 2.5% Gel
Source: ClinicalTrials.gov NCT01188538 ↗Enrolled (actual)
40
Serious AEs
0.0%
Results posted
Jul 2011
Primary outcomePrimary: Change From Baseline (Log10 Cfu/cm²) in Count of Follicular P. Acnes — -1.94; -1.56 Log10 cfu/cm²
Summary
The purpose of this study is to evaluate the antibacterial activity of Epiduo® Gel (Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel) on P. acnes compared to that of Benzoyl Peroxide 2.5% Gel.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change From Baseline (Log10 Cfu/cm²) in Count of Follicular P. Acnes |
-1.94; -1.56 | — |
| SECONDARY Percent Change (%) in Inflammatory Lesion Counts |
-62.8; -68.1 | — |
Eligibility Criteria
Inclusion Criteria
- Subjects with facial acne,
- Subjects with high levels of P. acnes counts on the forehead
Exclusion Criteria
- Female Subjects who are pregnant, nursing or planning a pregnancy during the study,
- Subjects with acne conglobata, acne fulminans, secondary acne
- Subjects with known or suspected allergy to one of the test product
Data sourced from ClinicalTrials.gov (NCT01188538). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.