N/A Completed N=25

Performance-Enhancing Effects of Platelet-Rich Plasma (PRP) Injections

Tendinopathy · Rheumatic Diseases

Source: ClinicalTrials.gov NCT01200875 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Dec 2016

Primary outcomePrimary: Blood Growth Factor Concentrations — 1.078 IGF-1 fold-change from baseline @ 24h

Summary

Platelet-Rich Plasma (PRP) has been banned in competitive athletes because some people think it may enhance athletic performance. However, there is very little published research to support or undermine this point of view. The purposes of this study are: (1) To assess the effects of local platelet-rich plasma (PRP) therapy on systemic levels of growth factors with suspected or known performance-enhancing effects; and (2) To understand whether the effect of PRP therapy on these growth factors differs between intramuscular and intratendinous PRP injections. This research study is looking for 40 people who are receiving platelet-rich plasma therapy for a tendon or muscle injury. The study involves collecting seven blood samples (2 teaspoons each) from each patient, before and after the PRP treatment. Blood samples may be donated at any location of the patient's choosing, and participants will be paid for their time.

Outcome Measures

Outcome	Result	p-value
PRIMARY Blood Growth Factor Concentrations	1.078	—

Eligibility Criteria

Inclusion Criteria

Male and female patients 18-50 years old, receiving ultrasound-guided intratendinous or intramuscular PRP injections

Exclusion Criteria

History of cancer, diabetes, hormone-replacement therapy, or abnormal nutritional habits.
Contraindications for PRP therapy itself:
preexisting coagulation defects including thrombocytopenia
hypofibrinogenemia
anticoagulation medications
hypersensitivity to bovine products, which may be used for platelet activation.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01200875). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.