N/A
Completed N=10
Clinical Evidence of pH Dependent ß2 Adrenergic Transport Mechanisms in the Airway
Healthy Volunteers
Source: ClinicalTrials.gov NCT01216748 ↗
Enrolled (actual)
10
Serious AEs
0.0%
Results posted
Dec 2014
Primary outcomePrimary: Changes in Airway Blood Flow After 180μg Albuterol by Inhalation (ΔQaw) vs Baseline — 16.8; 14.5; -0.2; 2.0 changes from baseline in μl.min-1.ml-1
Summary
The purpose of this study was to determine if airway pH has an effect on albuterol-induced vasodilation in the airway. Methods: Ten healthy volunteers performed the following respiratory maneuvers: quiet breathing, hypocapnic hyperventilation, hypercapnic hyperventilation, and eucapnic hyperventilation
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Changes in Airway Blood Flow After 180μg Albuterol by Inhalation (ΔQaw) vs Baseline |
16.8; 14.5; -0.2; 2.0 | — |
| SECONDARY Exhaled Breath Condensate (EBC) pH Variation |
6.39; 6.31; 6.59; 5.88 | — |
Eligibility Criteria
Inclusion Criteria
- Lifetime non-smokers
- FEV1 > 80% predicted value and FEV1/FVC > 0.75
Exclusion Criteria
- Cardiovascular disease or use of cardiovascular or vasoactive drugs;
- Lung disease or use of airway drugs (i.e. inhaled corticosteroids, β adrenergic agonists);
- Respiratory infection during the 4 weeks preceding the study
- Use of systemic glucocorticoids within 4 weeks of the study
- Pregnant or nursing females
Data sourced from ClinicalTrials.gov (NCT01216748). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.