N/A N=4,210 Randomized Double-blind Prevention

A Cluster-randomized Cross-over Trial Evaluating the Comparative Effectiveness of Three Skin Antiseptic Interventions

Bacteremia

Bottom Line

View on ClinicalTrials.gov: NCT01216761 ↗

Enrolled (actual)

4,210

Serious AEs

0.0%

Results posted

Nov 2012

Primary outcome: Primary: Blood Culture Contamination — 41; 32; 25 blood culture sets

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Iodine tincture (Drug); Chlorhexidine gluconate (Drug); Povidone iodine (Drug)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: University of Michigan
Primary completion: Sep 2009

Outcome Measures

Outcome	Result	p-value
PRIMARY Blood Culture Contamination	41; 32; 25	—

Summary

Background: Contaminated blood cultures result in unnecessary antibiotic use, increased length of stay, and additional laboratory tests, all of which increase healthcare costs. While the optimal skin antisepsis agent for reducing blood culture contamination is not known, the cost of various agents differs substantially. Objective: To determine the relative rates of blood culture contamination for 3 skin antisepsis interventions - 10% povidone iodine aqueous solution (PI), 2% iodine tincture (IT) and 2% chlorhexidine gluconate in 70% isopropyl alcohol (CHG) - when used by dedicated phlebotomy teams to obtain peripheral blood cultures in adult non-ICU medical and surgical patients.

Eligibility Criteria

Inclusion Criteria

Patient on general medical, surgical, and cardiology floors
Receipt of a peripheral blood draw for blood culture collection
Blood draw performed by phlebotomy team

Exclusion Criteria

None

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Data sourced from ClinicalTrials.gov (NCT01216761). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.