N/A Completed N=200 Randomized Triple-blind Treatment

Penicillin and Metronidazole in Treatment of Peritonsillar Abscess

Peritonsillar Abscess

Source: ClinicalTrials.gov NCT01255670 ↗

Enrolled (actual)

200

Serious AEs

0.0%

Results posted

May 2021

Primary outcomePrimary: Number of Participants With Recurrence of Peritonsillar Abscess — 10; 10 Participants — p=0.05

Summary

Treatment of peritonsillar abscess varies. To study whether broad spectrum antibiotics are required in addition to abscess drainage, a prospective, double blind, placebo-controlled, randomized study on 200 adult patients with peritonsillar abscess is performed. 100 patients are given penicillin and metronidazole and 100 patients get penicillin and placebo. Recovery and recurrence are analyzed.

Outcome Measures

Outcome	Result	p-value
PRIMARY Number of Participants With Recurrence of Peritonsillar Abscess	10; 10	0.05
SECONDARY Number of Participants Recovering From Peritonsillar Abscess	74; 80	0.05

Eligibility Criteria

Inclusion Criteria

referring doctor suspects peritonsillar abscess
patient is voluntary
patient has daily access to his/her e-mail
patient speaks and understands Finnish of Swedish
female patients have adequate birth-control method
patient has peritonsillar abscess

Exclusion Criteria

allergy to penicillin
allergy to metronidazole
use of metronidazole in preceding one month
pregnancy
breast-feeding
renal insufficiency
liver insufficiency
alcoholism (drunk at least once a week)
participant in another clinical trial at the moment
treatment of peritonsillar abscess requires in-patient care
tonsillectomy during the next 30 days
army recruit

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01255670). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.