Phase 4
Completed N=330
Valproate Versus Ketorolac Versus Metoclopramide
Source: ClinicalTrials.gov NCT01267864 ↗Enrolled (actual)
330
Serious AEs
0.0%
Results posted
Jun 2018
Primary outcomePrimary: Headache Pain Level on a 0-10 Verbal Scale — 4.7; 3.9; 2.8 units on a scale
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
This randomized study is testing 3 different intravenous medications to see which one is best for acute migraine. The three medications are metoclopramide, valproate, and ketorolac.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Headache Pain Level on a 0-10 Verbal Scale |
4.7; 3.9; 2.8 | — |
| SECONDARY Participants Who Achieve Sustained Headache Freedom for 24 Hours |
12; 17; 4 | — |
| SECONDARY Satisfaction With Medication |
65; 42; 28 | — |
| SECONDARY Adverse Event |
24; 33; 25 | — |
Eligibility Criteria
Inclusion Criteria
- IHS migraine without aura
- IHS probable migraine (all migraine without arua criteria must be met except duration may be >72 hours or <4 hours)
Exclusion Criteria
- Allergy or contra-indication to investigational medication
Data sourced from ClinicalTrials.gov (NCT01267864). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.