N/A Completed N=22 Randomized Double-blind Treatment

Trial of Alternating Current Stimulation in Optic Neuropathy

Optic Nerve Diseases · Optic Nerve Injuries · Optic Neuropathies

Source: ClinicalTrials.gov NCT01270126 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Sep 2013

Primary outcomePrimary: Detection Accuracy (DA) Change in Percent Over Baseline Within Defective Visual Field Sectors — 24.75; 39.16 percent change

Summary

Non-invasive brain stimulation can increase cortical excitability in the visual system, but it is not known if this is of clinical value. The investigators now assessed if repetitive, transcranial alternating current stimulation (rtACS) can improve visual field size in patients with optic nerve damage. The investigators hypothesized that rtACS would improve visual functions within the defective visual field sectors of the visual field (primary outcome measure).

Outcome Measures

Outcome	Result	p-value
PRIMARY Detection Accuracy (DA) Change in Percent Over Baseline Within Defective Visual Field Sectors	24.75; 39.16	—
SECONDARY Other Visual and EEG Parameters	—	—

Eligibility Criteria

Inclusion Criteria

patients with optic nerve lesion
stable visual field defect with residual vision
lesion age at least 6 months

Exclusion Criteria

heart pacemakers and any metal artefacts in head and truncus
epileptic seizure within the last 3 years
photosensitive epilepsy as determined by EEG
mental diseases (schizophrenia etc.)
unstable diabetes, diabetes causing diabetic retinopathy
macular degeneration, maculopathy with decimal visual acuity below 0.4
high blood pressure
instable or high level of intraocular pressure (i.e. >27 mmHg)
presence of an un-operated tumor anywhere in the body
total blindness
primary or secondary glaucoma
pathological nystagmus

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01270126). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.