Phase 4
Completed N=62
Efficacy of Repyflec Cognitive Remediation Group Training in Schizophrenia
Indication for Modification of Patient Cognitive Status
Source: ClinicalTrials.gov NCT01279070 ↗
Enrolled (actual)
62
Serious AEs
0.0%
Results posted
Aug 2013
Primary outcomePrimary: Executive Function — 99.5; 95.7; 2.7; 1.7 units on a scale — p=<0.05
Summary
The purpose of this study was to develop an integrative intervention for schizophrenia taking into account previous efficacious therapies. Thus, our aim was to evaluate the efficacy of our cognitive remediation group training: Problem Solving and Cognitive Flexibility training (REPYFLEC), focused to improve neurocognition and functioning in schizophrenia patients. We hypothesized that training executive function and metacognition would allow us to achieve improvements in neurocognition, functioning and psychiatric symptoms of patients with schizophrenia.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Executive Function |
101.8; 94.5; 3; 1.7 | <0.05 sig |
| SECONDARY Psychosocial Functioning |
135.7; 132.9; 107; 107.2 | <0.05 sig |
| SECONDARY Psychiatric Symptoms |
12.9; 14; 17.6; 16.9; 30.8; 30.8 | <0.05 sig |
Eligibility Criteria
Inclusion Criteria
- Diagnosis of schizophrenia or schizoaffective disorder
- More than 2 years illness duration
- Literate
- Mini Mental Status Examination score over 24
- Global Assessment of Functioning scores between 40 and 70
Exclusion Criteria
- Current acute illness exacerbation
- Mental Retardation
- Neurological disorder which impairs cognition
- Currently participating in social skills training or cognitive remediation
- Change of antipsychotic medication one month before the trial or during the 40 study weeks
- Diagnosis of alcohol or drug dependence within 6 months of trial commencement.
Data sourced from ClinicalTrials.gov (NCT01279070). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.