Phase 2 N=24 Randomized Triple-blind Treatment

Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and Wrinkles

Photodamaged Skin · Wrinkles

Bottom Line

View on ClinicalTrials.gov: NCT01283464 ↗

Enrolled (actual)

Serious AEs

12.5%

Results posted

Aug 2013

Primary outcome: Primary: Global Photodamage Severity — 4.8; 5.45 units on a scale

Study Design & Population

Study type: Interventional
Phase: Phase 2
Interventions: Retinol (Drug); Tretinoin (Drug)
Age: Adult, Older Adult · 35+ yrs
Sex: All
Sponsor: Johns Hopkins University
Primary completion: Dec 2011

Outcome Measures

Outcome	Result	p-value
PRIMARY Global Photodamage Severity	4.8; 5.45	—

Summary

The purpose of this study is to assess the comparative efficacy of retinol 1.0% and tretinoin 0.02% in minimizing wrinkles, discoloration, roughness, and other signs of moderate to severe photodamage. Our hypothesis is that both products will be of comparable benefit.

Eligibility Criteria

Inclusion Criteria

Age 35 or over
Moderate to severe photodamage

Exclusion Criteria

History of facial cosmetic surgery, facial resurfacing procedures, deep peels, or facial fillers
History of keloids or hypertrophic scars
Use of oral steroids or oral retinoids (such as Accutane) in past 6 months

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01283464). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.