N/A N=22 Randomized Treatment

Improving the Sleep and Circadian Rhythms of Mechanically Ventilated Patients

Critical Illness · Sleep Deprivation · Respiratory Failure · Sleep Disorders, Circadian Rhythm

Bottom Line

View on ClinicalTrials.gov: NCT01284140 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

May 2018

Primary outcome: Primary: Circadian Timing — 3.6; -2.4 hours — p=0.37

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Sleep and circadian rhythm promotion (Behavioral); Usual care (Behavioral)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Brian Gehlbach
Primary completion: Dec 2016

Outcome Measures

Outcome	Result	p-value
PRIMARY Circadian Timing	3.6; -2.4	0.37
SECONDARY Normal Circadian Timing	3; 1	0.55
SECONDARY Circadian Amplitude	36.6; 11.0	0.03 sig
SECONDARY Spectral Edge Frequency 95%	—	—
SECONDARY Delirium	2; 2	—

Summary

The goal of this project is to determine whether the sleep and circadian rhythms of critically ill patients undergoing mechanical ventilation can be improved through practical strategies that can be employed at the bedside.

Eligibility Criteria

Inclusion Criteria

Age 18 years or older
Receiving mechanical ventilation and intravenous sedation

Exclusion Criteria

Debilitating central nervous system disease or degenerative disorder
Active seizures
Persistent coma
Renal failure requiring dialysis
Expected to be extubated within 24 hours
Currently receiving neuromuscular blocker

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01284140). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.