Phase 2
Completed N=50
Study to Evaluate Switching From a Regimen Consisting of the Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate Single-Tablet Regimen (STR) to the Emtricitabine/Rilpivirine/Tenofovir Disoproxil Fumarate STR
Source: ClinicalTrials.gov NCT01286740 ↗Enrolled (actual)
50
Serious AEs
2.0%
Results posted
Apr 2013
Primary outcomePrimary: Percentage of Participants With HIV-1 RNA < 50 Copies/mL at Week 12 (FDA Snapshot Analysis) — 100 percentage of participants
Summary
The purpose of this Phase 2b study was to evaluate the efficacy and safety of the emtricitabine/rilpivirine/tenofovir disoproxil fumarate (FTC/RPV/TDF) STR, after switching from the efavirenz (EFV)/FTC/TDF STR at baseline, in maintaining HIV-1 RNA < 50 copies/mL at Week 12. HIV-infected patients were enrolled if they had received EFV/FTC/TDF for ≥ 3 months prior to study start, were experiencing safety or tolerability concerns (in particular, EFV-related intolerance), and wished to change to an alternate, better-tolerated regimen.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Percentage of Participants With HIV-1 RNA < 50 Copies/mL at Week 12 (FDA Snapshot Analysis) |
100 | — |
| SECONDARY Percentage of Participants With HIV-1 RNA < 50 Copies/mL at Week 24 (FDA Snapshot Analysis) |
100 | — |
| SECONDARY Percentage of Participants With HIV-1 RNA < 50 Copies/mL at Week 48 (FDA Snapshot Analysis) |
93.9 | — |
| SECONDARY Plasma Concentration of RPV and EFV at Week 1 |
31.6; 234.5 | — |
| SECONDARY Plasma Concentration of RPV and EFV at Week 2 |
52.3; 78.5 | — |
| SECONDARY Plasma Concentration of RPV and EFV at Week 4 |
65.5; 10.0 | — |
| SECONDARY Plasma Concentration of RPV and EFV at Week 6 |
67.8; 1.9 | — |
| SECONDARY Plasma Concentration of RPV and EFV at Week 8 |
76.0; NA | — |
| SECONDARY Plasma Concentration of RPV at Week 12 |
89.0 | — |
| SECONDARY Plasma Concentration of EFV at Week 12 |
45.2 | — |
| SECONDARY Plasma Concentration of RPV at Week 24 |
74.1 | — |
| SECONDARY Plasma Concentration of RPV at Week 36 |
85.5 | — |
| SECONDARY Plasma Concentration of RPV at Week 48 |
77.6 | — |
Eligibility Criteria
Inclusion Criteria
- Ability to understand and sign a written informed consent form
- Receiving EFV/FTC/TDF continuously for ≥ 3 months preceding the screening visit
- Plasma HIV-1 RNA concentrations (at least two measurements) at undetectable levels for ≥ 8 weeks prior to the screening visit and HIV-1 RNA 50 copies/mL measured at two consecutive time points after first achieving HIV RNA 5 x ULN eligible if serum lipase ≤ 5 x ULN)
- Adequate renal function (estimated glomerular filtration rate ≥ 50 mL/min according to the Cockcroft-Gault formula)
- Males and Females of childbearing potential must have agreed to utilize highly effective contraception methods (two separate forms of contraception, one of which must be an effective barrier method, or be nonheterosexually active, practice sexual abstinence, or have a vasectomized partner) from screening throughout the duration of the study period and for 60 days following the last dose of study drug.
- Age ≥ 18 years
- Life expectancy ≥ 1 year
Exclusion Criteria
- A new AIDS-defining condition diagnosed within 21 days prior to screening
- Females who were breastfeeding
- Positive serum pregnancy test (female of childbearing potential)
- Proven or suspected acute hepatitis in the 21 days prior to study entry
- Subjects receiving drug treatment for Hepatitis C, or subjects anticipated to receive treatment for Hepatitis C during the course of the study, or with a history of liver disease
- Was experiencing decompensated cirrhosis
- Implanted defibrillator or pacemaker
- Current alcohol or substance abuse judged by the Investigator to potentially interfere with subject compliance
- History of malignancy within the past 5 years or ongoing malignancy other than cutaneous Kaposi's sarcoma, basal cell carcinoma, or resected, noninvasive cutaneous squamous carcinoma
- Active, serious infections requiring parenteral antibiotic or antifungal therapy within 21 days prior to Baseline
- All investigational drugs
- Ongoing therapy or anticipated need to initiate drugs or herbal/natural supplements during the study that were contraindicated or not recommended for use as indicated in the protocol, including drugs not to be used with FTC, RPV, and TDF; or subjects with known allergies to the excipients of the FTC/RPV/TDF STR
- Participation in any other clinical trial without prior approval from the sponsor was prohibited while participating in this trial
- Treatment with immunosuppressant therapies or chemotherapeutic agents within 3 months of study screening, or expected to receive these agents or systemic steroids during the study (eg, corticosteroids, immunoglobulins, and other immune- or cytokine-based therapies)
- Any other clinical condition or prior therapy that, in the opinion of the Investigator, would make the subject unsuitable for the study or unable to comply with the dosing requirements
Data sourced from ClinicalTrials.gov (NCT01286740). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.