N/A Completed N=14 Treatment

Fresh Versus Old Red Blood Cells for Transfusion

Iron, Abnormal Blood Level · Other Abnormal Blood Chemistry

Source: ClinicalTrials.gov NCT01319552 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jun 2015

Primary outcomePrimary: Measure of Non-transferrin-bound Iron — 0.16; 3.17 μM

Summary

Packed red blood cell units destined for transfusion can be stored for up to 42 days prior to transfusion based on Food and Drug Administration (FDA) guidelines. Recent studies suggest that certain patients transfused with blood stored for longer duration have poorer outcomes than patients transfused fresher blood. The investigators' hypothesis is that the delivery of an immediate and substantial load of hemoglobin-associated iron from a stored unit of blood leads to changes that explain the differences in outcome between patients transfused old versus fresh blood. The investigators propose to test this hypothesis in humans by transfusing an individual's own blood, both fresh and after storage, and comparing levels of various outcome measures.

Outcome Measures

Outcome	Result	p-value
PRIMARY Measure of Non-transferrin-bound Iron	0.16; 3.17	—

Eligibility Criteria

Inclusion Criteria

healthy
male body weight >130 lbs, female body weight > 155 lbs
male height >5'1", female height >5'5"
hemoglobin >13.3 g/dL

Exclusion Criteria

ineligible for donation based on the New York Blood Center autologous blood donor questionnaire
systolic blood pressure >180 or 100 or 100
temperature >99.5 F prior to donation
temperature >100.4 F or subjective feeling of illness prior to transfusion
positive results on standard blood donor infectious disease testing
pregnancy.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01319552). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.