N/A
N=94
Saphenous Nerve Block Versus Femoral Nerve Block for Total Knee Arthroplasty
Total Knee Arthroplasty
Bottom Line
View on ClinicalTrials.gov: NCT01333943 ↗Enrolled (actual)
94
Serious AEs
0.0%
Results posted
Dec 2017
Primary outcome: Primary: Quadriceps Muscle Strength — 7.3; 2.2 kilogram-force
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Study Group: Experimental (Procedure); Control Group (Procedure)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Hospital for Special Surgery, New York
- Primary completion
- Nov 2011
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Quadriceps Muscle Strength |
7.3; 2.2 | — |
| SECONDARY Total Opioid Usage |
36.6; 35.8 | — |
| SECONDARY NRS Pain Scores at Rest |
1.7; 0.9 | — |
| SECONDARY Patient Satisfaction With the Nerve Block. |
8.8; 9.1 | — |
| SECONDARY Incidence of Postoperative Complications. |
0; 0 | — |
| SECONDARY Total Length of Hospital Stay |
3.7; 3.6 | — |
Summary
Currently, the regional anesthetic standard of care for total knee replacement surgery is combined spinal/epidural, with or without a femoral nerve block, or FNB. Lasting approximately 18 hours, the FNB works by numbing the femoral nerve (and its branches), which is the major nerve controlling the knee joint. The femoral nerve also provides movement and sensation. While this regional anesthetic technique offers significant postoperative pain relief, it is possible that it may cause muscle weakness and increase patients' recovery time. Hence there is a need for an alternative technique, one that may help minimize postoperative pain as effectively as the FNB, while not causing weakness of the quadriceps muscle.
The saphenous nerve, a branch of the femoral nerve, provides sensation to the knee. Thus it is hypothesized that by "blocking" or anesthetizing the saphenous nerve with local anesthetic closer to where it branches off, the area around and below the knee will feel numb. Yet unlike with the FNB, the quadriceps muscle itself will still be able to function.
Patients will be randomized to receive FNB or saphenous nerve block. Quadriceps strength will be tested using a dynamometer before surgery (baseline), 6-8 hours following anesthesia administration, and on postoperative days 1 and 2. It is hypothesized that patients who receive FNB will experience a 50% decrease in quadriceps strength compared to baseline.
Eligibility Criteria
Inclusion Criteria
- All patients ages 18-90 undergoing primary unilateral total knee arthroplasty
- Planned use of neuraxial anesthesia
- Ability to follow study protocol
- American Society of Anesthesiology (ASA) Class 1-3
Exclusion Criteria
- Contraindication to a spinal or epidural anesthetic
- Chronic opioid use (defined as daily or almost daily use of opioids for >3 months)
- Hypersensitivity and/or allergy to local anesthetics
- Intraoperative use of any volatile anesthetic
- Patients with a pre-existing neuropathy on the operative limb
- Contraindication to a femoral nerve block or saphenous nerve block
- Allergy to any of the study medications
- Non-English speaking patients
Data sourced from ClinicalTrials.gov (NCT01333943). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.