A Multi-center, Placebo-controlled Study to Evaluate the Safety of GSK716155 and Its Effects on Myocardial Metabolism, Myocardial Function, and Exercise Capacity in Patients With NYHA Class II/III Congestive Heart Failure

Inclusion Criteria

• Chronic dilated cardiomyopathy of ischemic or non-ischemic origin
• Clinically stable on optimal therapies for at least 3 months prior to screening/baseline visit.
• Left ventricular ejection fraction greater than or equal to 40% as assessed by any measurement in the previous 24 months.
• NYHA Class II/III heart failure for a minimum of 6 months prior to enrolment
• Male or female between 21 and 75 years of age inclusive, at the time of signing the informed consent. However the optimal age range for this study will be 40 to 65 years of age.
• A female subject is eligible to participate if she is of:

Non-childbearing potential defined as pre-menopausal females with a documented tubal ligation or hysterectomy; or postmenopausal defined as 12 months of spontaneous amenorrhea [in questionable cases a blood sample with simultaneous follicle stimulating hormone (FSH) > 40 MlU/ml and estradiol 1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin 100 pg./mL

• Triglycerides > 850 mg/dL
• History of significant gastrointestinal surgery, including gastric bypass and banding, antrectomy, Roux-en-Y bypass, gastric vagotomy, small bowel resection, or surgeries thought to significantly affect upper gastrointestinal function.
• History of regular alcohol consumption within 6 months of the study defined as:

For UK: an average weekly intake of >21 units for males or >14 units for females. One unit is equivalent to 8 g of alcohol: a half-pint (~240 ml) of beer, 1 glass (125 ml) of wine or 1 (25 ml) measure of spirits.

For US: an average weekly intake of >14 drinks for males or >7 drinks for females. One drink is equivalent to 12 g of alcohol: 12 ounces (360 ml) of beer, 5 ounces (150 ml) of wine or 1.5 ounces (45 ml) of 80 proof distilled spirits.

• The subject has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer).
• Exposure to more than four new chemical entities within 12 months prior to the first dosing day.
• Known allergy or history of sensitivity to albiglutide, any other GLP-1 analogue, , or Baker's yeast.
• Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period.
• Pregnant females as determined by positive serum or urine hCG test at screening or prior to dosing.
• Lactating females.
• Unwillingness or inability to follow the procedures outlined in the protocol (e.g.. related to psychiatric disorder)
• Subject is mentally or legally incapacitated.
• Known diagnosis of diabetes mellitus, fasting glucose >140mg/dL, or HbA1c > 7%.
• Uncorrected thyroid disease manifest as an abnormal thyroid-stimulating hormone (TSH) (outside reference range at screening).
• Other medical problems with life expectancy less than 1yr.
• Other causes of cardiomyopathy or left ventricular dysfunction including:

Uncorrected primary obstructive or regurgitant valvular disease Restrictive cardiomyopathy due to amyloidosis, hemochromatosis, sarcoidosis or other cause Cardiac hypertrophy with wall thickness >1.5cm Alcohol-induced cardiomyopathy Women with heart failure during the 12 months following childbirth. Complex congenital heart disease Anthracycline induced cardiomyopathy

• Subjects with genetic disorders of skeletal muscle (e.g. Duchenne muscular dystrophy)
• Clinically significant pericardial disease.
• Listed as a status 1A or 1B on heart transplant waiting list.
• History of deep vein thrombosis or a known coagulation disorder
• History of pancreatitis
• History of or family history of medullary thyroid carcinoma
• History of or family history of multiple endocrine neoplasia type 2
• History of renal dysfunction with estimated GFR 170 mmHg; or diastolic blood pressure >110 mgHg at screening.
• Inability of