Phase 2
Completed N=51
The Cognitive Enhancing Effects of D-Cycloserine Among Non-Demented Elderly
Treatment · Placebo
Source: ClinicalTrials.gov NCT01361633 ↗
Enrolled (actual)
51
Serious AEs
0.0%
Results posted
Jun 2012
Primary outcomePrimary: California Verbal Learning Test-II (CLVT-II) — 55.84; 55.39 age adjusted t-scores
Summary
The goal of this study is to determine whether a study medication (d-cycloserine) improves the ability of older adults to perform on tests of neuropsychological functioning. Tests of neuropsychological functioning assess attention, memory, and executive functioning skills (for example, problem-solving, planning and organizing skills). It was hypothesized that participants who received study medication would perform better on neuropsychological tests than would participants who received the sugar pill.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY California Verbal Learning Test-II (CLVT-II) |
55.84; 55.39 | — |
| SECONDARY Continuous Performance Test |
479.50; 507.80 | — |
| SECONDARY Controlled Oral Word Association Test |
49.58; 46.91 | — |
| SECONDARY Wisconsin Card Sort Test |
53.50; 53.70 | — |
| SECONDARY Trails B |
52.16; 48.83 | — |
| SECONDARY Stroop |
44.68; 43.30 | — |
| SECONDARY Implicit Memory Task |
3.16; 2.00 | — |
Eligibility Criteria
Inclusion Criteria
- age 60 or older
- native English speaker
Exclusion Criteria
- diagnosis of current psychiatric disorder
- substance abuse past 3 months
- cognitive impairment
- neurological disorder
- poor health or unstable medical condition
- positive toxicology screen
- current use of isoniazid
- current use of trecator
- severe renal insufficiency
Data sourced from ClinicalTrials.gov (NCT01361633). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.