Phase 2
Completed N=101
Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty
Acute Blood Loss Anemia · Osteoarthritis, Knee
Source: ClinicalTrials.gov NCT01370460 ↗
Enrolled (actual)
101
Serious AEs
—
Results posted
Jul 2013
Primary outcomePrimary: Blood Loss — 1293.1; 940.2 mL
Summary
This study aims to assess postoperative blood loss and transfusion rates in total knee replacement after one-time administration of topical tranexamic acid.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Blood Loss |
1293.1; 940.2 | — |
| SECONDARY Postoperative Transfusion Rate |
0; 4 | — |
Eligibility Criteria
Inclusion Criteria
- All adult patients over age eighteen
- Primary unilateral total knee arthroplasty at Henry Ford Hospital (Detroit, Michigan, United States) and Henry Ford West Bloomfield Hospital (West Bloomfield, Michigan, United States)
Exclusion Criteria
- patient history of venous thromboembolic disease or coagulopathy
- use of anticoagulant medications within 7 days of surgery
- history of arterial embolic disease
- history of Class III or IV heart failure
- renal failure
- intraoperative cardiovascular, pulmonary, orthopaedic, or anesthetic complication (MI, intraoperative fracture, vasopressor support, emergent intubation).
Data sourced from ClinicalTrials.gov (NCT01370460). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.