A Bioavailability Study of LY2452473 and Tadalafil

Inclusion Criteria

• Overtly healthy male, as determined by medical history and physical examination
• Are between a body mass index of 18.5 and 30 kilograms per meter squared (kg/m²), inclusive at screening
• Have clinical laboratory test results within normal reference range for the population or investigator site, or results with acceptable deviations that are judged to be not clinically significant by the investigator
• Normal blood pressure and heart rate (HR; sitting) as determined by the investigator
• Have venous access sufficient to allow blood sampling
• Are reliable and willing to make themselves available for the duration of the study, and will abide by the research unit policies and procedures and study restrictions
• Have given written informed consent approved by Lilly and the ethical review board (ERB) governing the site
• Men must agree to use a reliable method of birth control (for example, vasectomy, condom with contraceptive foam, abstinence, or female partner's use of oral contraceptives or Norplant®; a reliable barrier method of birth control [diaphragm with contraceptive jelly]; or intrauterine device), during the study and for 1 month following the last dose of study drug

Exclusion Criteria

• Have known allergies to LY2452473, tadalafil, or related compounds
• History of severe allergies or multiple adverse drug reactions
• Have a history or presence of cardiovascular, respiratory, hepatic (including history of cholecystectomy), renal, gastrointestinal, endocrine, hematological, or neurological disorders capable of significantly altering the absorption, metabolism, or elimination of drugs; of constituting a risk when taking the study medication; or of interfering with the interpretation of data
• Any abnormality in the 12-lead electrocardiogram (ECG) that in the opinion of the investigator places the subject at an unacceptable risk for study participation
• Show evidence of significant active neuropsychiatric disease
• History of significant retinal pathology
• Have a history of glaucoma
• Have a history of unexplained syncope episodes
• Show evidence of hepatitis C and/or positive hepatitis C antibody
• Show evidence of hepatitis B and/or positive hepatitis B surface antigen
• Show evidence of human immunodeficiency virus (HIV) and/or positive HIV antibodies
• Intended use of over-the-counter or herbal remedies within 7 days prior to dosing or during the study
• Intended use of prescription medication within 14 days prior to dosing or during the study
• Are not willing to refrain from consumption of any food, or drink any beverage containing grapefruit, pomelo, or starfruit for at least 2 weeks prior to the start of the study until its conclusion
• Heavy caffeine drinkers defined by a regular intake of more than 5 cups of coffee (or equivalent in xanthine-containing beverages) per day or subjects who have not had consistent daily caffeine consumption for 1 month prior to study entry or subjects not willing to maintain consistent caffeine consumption during the study
• Use of drugs of abuse, as evidenced by history, and/or positive findings on urinary drug screening
• Have an average weekly alcohol intake that exceeds 14 units per week or are unwilling to stop alcohol consumption for the duration of the study (1 unit = 12 ounces [oz] or 360 milliliters (mL) of beer; 5 oz or 150 mL of wine; 1.5 oz or 45 mL of distilled spirits)
• Is currently a smoker or uses tobacco products on a regular basis and has not had consistent daily tobacco use for 1 month prior to study entry or subjects not willing to maintain consistent tobacco use during the study
• Have a history of blood donation of 1 unit (approximately 450 mL) or more in the last 3 months prior to study entry
• Have previously completed or withdrawn from this study or any other study investigating LY2452473
• Within 30 days of the initial dose of study drug, have received treatment with a drug that has not received regulatory approval for any indi