N/A Completed N=45 Randomized Single-blind Prevention

Effect of Beta-Glucan on Cholesterol Lowering

Hypercholesterolemia

Source: ClinicalTrials.gov NCT01408719 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Mar 2014

Primary outcomePrimary: Changs in Total Cholesterol — -0.42; -0.60; -0.46; -0.30 mmol/L

Summary

The primary aim of this study is to determine whether the cholesterol-lowering efficacy of barley b- glucan varied as function of molecular weight (MW) and the total daily amount consumed. Our second aim is to investigate the mechanism responsible for the action, specifically, whether β-glucan lowers circulating cholesterol concentration via inhibiting cholesterol absorption and synthesis. Thirdly, we aim to determine if any gene-diet interactions are associated with cholesterol lowering by barley β-glucan. In addition, we aim to investigate the alteration of the gut microbiota after β-glucan consumption and the correlation between the altered gut microbiota and cardiovascular disease risk factors.

Outcome Measures

Outcome	Result	p-value
PRIMARY Changs in Total Cholesterol	-0.42; -0.60; -0.46; -0.30	—
PRIMARY Changes in LDL Cholesterol	—	—
SECONDARY Cholesterol Absorption/Synthesis	—	—
SECONDARY Potential Gene-nutrient Interactions: CYP7A1 and APOE	—	—
SECONDARY Changes in Body Weight and Waist Circumference(WC)	—	—

Eligibility Criteria

Inclusion Criteria

BMI 20-40 kg/m2
Fasting cholesterol levels of 5.0-8.0 mmol/L
Fasting serum LDL cholesterol levels of 2.7-5.0 mmol/L

Exclusion Criteria

Pregnant or lactating
Taking lipid lowering medication or nutritional supplements that affect blood lipids
Dietary restrictions which would affect consuming the study diet for 5-wk for four study phases.
Not deemed healthy by study physician

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01408719). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.