N/A
Completed N=300
LOGIC-Insulin Algorithm-guided Versus Nurse-directed Blood Glucose Control During Critical Illness
Source: ClinicalTrials.gov NCT01420302 ↗Enrolled (actual)
300
Serious AEs
0.0%
Results posted
Aug 2024
Primary outcomePrimary: Glycemic Penalty Index (GPI) During the Intervention — 9.8; 12.4 units on a scale — p=<0.0001
Summary
The LOGIC-Insulin computerized software algorithm will be compared with a nurse-directed protocol, both targeting a blood glucose level of 80-110 mg/dL, in critically ill patients
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Glycemic Penalty Index (GPI) During the Intervention |
9.8; 12.4 | <0.0001 sig |
| SECONDARY Proportion of Patients With Severe Hypoglycemia (<40 mg/dL) During the Intervention |
— | — |
| SECONDARY Incidence of Severe Hypoglycemia (<40 mg/dL) During the Intervention |
— | — |
| SECONDARY Blood Glucose Level Per Treatment Group During the Intervention |
— | — |
| SECONDARY Hyperglycemic Index (HGI) During the Intervention |
— | — |
| SECONDARY Daily Maximal Blood Glucose Difference During the Intervention |
— | — |
| SECONDARY Proportion of Patients With Common Hypoglycemia (<60 mg/dL) During the Intervention |
— | — |
| SECONDARY Interval Between Blood Glucose Measurements During the Intervention |
— | — |
| SECONDARY Percentage of Time in Target Zone (80-110 mg/dL) During the Intervention |
— | — |
| SECONDARY Length of Stay in ICU |
— | — |
| SECONDARY Length of Stay in Hospital |
— | — |
| SECONDARY Hospital Mortality |
— | — |
| SECONDARY Incidence of Common Hypoglycemia (<60 mg/dL) During the Intervention |
— | — |
Eligibility Criteria
Inclusion Criteria
- Aged 18 years or more
- Admitted to the ICU
- Already receiving or needing insulin infusion for blood glucose control
Exclusion Criteria
- Not critically ill (eating, not mechanically ventilated)
- Pregnant or breastfeeding
- Previous inclusion into the trial
- Included in other trial
- Moribund
- Diabetes coma
- No arterial line available
Data sourced from ClinicalTrials.gov (NCT01420302). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.