N/A
N=15
Growth Hormone Treatment on Phosphocreatine Recovery in Obesity
Obese · Growth Hormone Secretion Abnormality
Bottom Line
View on ClinicalTrials.gov: NCT01421589 ↗Enrolled (actual)
15
Serious AEs
0.0%
Results posted
Jul 2014
Primary outcome: Primary: Phosphocreatine Recovery — 0.74 correlation coefficient — p=0.02
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Growth hormone treatment (Drug)
- Age
- Adult · 18+ yrs
- Sex
- Male
- Sponsor
- Massachusetts General Hospital
- Primary completion
- Mar 2013
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Phosphocreatine Recovery |
0.74 | 0.02 sig |
| SECONDARY Change in Circulating IGF-1 Concentration |
218 | <0.0001 sig |
| SECONDARY Change in Skeletal Muscle IGF-1 Gene Expression |
2.1 | <0.05 sig |
| SECONDARY Change in Body Composition |
-3 | <0.05 sig |
| SECONDARY Change in Inflammatory Marker |
-1.78 | <0.05 sig |
| SECONDARY Change in Insulin Sensitivity |
6 | <0.05 sig |
| SECONDARY Change in Phosphocreatine Recovery |
-10.2 | >0.05 |
Summary
Obesity is associated with reduced growth hormone (GH) secretion. Reduced GH secretion in obesity is associated with increased cardiovascular disease risk. However, it is not yet known how reduced GH increases cardiovascular disease risk in obesity. The investigators hypothesize that reduced GH contributes to dysfunction of the mitochondria. Therefore, the investigators hypothesize that treatment of obese subjects with reduced GH secretion with GH will improve mitochondrial function and that this improvement in mitochondrial function will contribute, in part, to the effects of GH to improve metabolic parameters in obesity. The investigators propose to study skeletal muscle mitochondria in obese subjects with reduced GH secretion using magnetic resonance spectroscopy and muscle biopsies before and after treatment with GH.
Eligibility Criteria
Inclusion Criteria
- Men age 18-60 years old
- BMI ≥ 30 kg/m2
- Waist circumference ≥ 102 cm
- Peak GH value of ≤ 4.2 μg/l on standard GHRH-arginine stimulation test
Exclusion Criteria
- Obesity due to a known secondary cause (Cushing's syndrome, hypothyroidism, etc) or a history of gastric bypass procedure.
- Subjects who have a known history of diabetes, fasting blood sugar >125 mg/dl or using any anti-diabetic drugs.
- Use of Aspirin, Clopidogrel (Plavix), Warfarin (Coumadin) or other anti-coagulants
- Subjects on testosterone, glucocorticoids, anabolic steroids, GHRH, GH or IGF-1 within 3 months of enrollment.
- Changes in lipid lowering or anti-hypertensive regimen within 3 months of screening
- History of pituitary tumor, hypopituitarism, pituitary surgery, pituitary/brain radiation or traumatic brain injury or any other condition known to affect the GH axis.
- Severe chronic illness including HIV, active malignancy or history of colon cancer.
- Hemoglobin 2.5 x upper limit normal, Creatinine >1.5 mg/dL, or PSA >5 ng/ml.
- Subject is currently enrolled in another investigational device or drug trial(s), or subject has received other investigational agent(s) within 28 days of baseline visit.
- Any condition judged by the patient's physician to cause this clinical trial to be detrimental to the patient.
- Contraindications to MRI scanning.
Data sourced from ClinicalTrials.gov (NCT01421589). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.