N/A
N=79
Instant and Lasting Relief Effects of Strontium Chloride/Potassium Nitrate Dentifrice on Dentin Hypersensitivity
Dentine Hypersensitivity
Bottom Line
View on ClinicalTrials.gov: NCT01426360 ↗Enrolled (actual)
79
Serious AEs
0.0%
Results posted
Dec 2011
Primary outcome: Primary: Tactile Hypersensitivity Scores Immediately After Topical Dentifrice Use — 19.47; 14.27 gram
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- control dentifrice (Other); strontium chloride/potassium nitrate dentifrice (Other)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Sun Yat-sen University
- Primary completion
- Sep 2011
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Tactile Hypersensitivity Scores Immediately After Topical Dentifrice Use |
19.47; 14.27 | — |
| PRIMARY Air Blast Hypersensitivity Scores Immediately After Topical Dentifrice Use |
1.93; 2.22 | — |
| PRIMARY Tactile Hypersensitivity Score After 3 Days of Dentifrice Use |
19.87; 14.27 | — |
| PRIMARY Air Blast Hypersensitivity Score 3 Days After Dentifrice Use |
1.8; 2.13 | — |
Summary
The objective of the present study was to compare the effects of a commercially available dentifrice containing 2% strontium chloride and 5% potassium nitrate in a silica base, versus a control dentifrice, containing exactly the same ingredients apart from strontium chloride and potassium nitrate, on the instant and lasting relief of DH.
Eligibility Criteria
Inclusion Criteria
- good oral and general health
- possessing at least two teeth (incisors, cuspids, bicuspids and first molars with exposed cervical dentin) with hypersensitivity on facial surfaces which satisfied a tactile hypersensitivity stimulus score of 10-50 grams of force (Yeaple probe) and an air blast stimulus score of 2 or 3(Schiff Cold Air Scale)
- provided informed consent and were available for the study duration
Exclusion Criteria
- progressive periodontitis, with teeth that had extensive restoration, suspected pulpitis, caries, cracked enamel or that were used as abutments for removable partial dentures,
- had hypersensitive teeth with a mobility greater than one
- had received periodontal treatment including surgery during the last year
- had used any other anti-hypersensitivity dentifrice or taken part in any other clinical trial, used any desensitizing agents during the last three months, or allergic to the ingredients of the dentifrices were excluded
- pregnant or breastfeeding women
- had taken the following drugs during the last month: anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory drugs or daily analgesics
Data sourced from ClinicalTrials.gov (NCT01426360). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.