N/A N=10 Basic Science

Controlled Adverse Environment: A Pilot Study to Evaluate Tear Film Stability and Tear Evaporation

Environmental Exposure

Bottom Line

View on ClinicalTrials.gov: NCT01448356 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Dec 2012

Primary outcome: Primary: Tear Evaporation Rate — 39.0; 44.8; 30.6; 26.7 Watt/meter^2

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: temperature and humidity (Procedure)
Age: Adult, Older Adult · 21+ yrs
Sex: All
Sponsor: Singapore Eye Research Institute
Primary completion: Apr 2012

Outcome Measures

Outcome	Result	p-value
PRIMARY Tear Evaporation Rate	39.0; 44.8; 30.6; 26.7	—
SECONDARY Tear Film Break up Time	5.9; 4.4; 5.0; 4.6	—

Summary

Dry eye and ocular surface disease account for a lot of morbidity and socio-economic burden in Asia and the rest of the world. This is a small pilot study to evaluate tear function under different conditions of humidity and temperature. This data will be useful for designing future trials in ocular surface and dry eye. The data will likely be used to propose a larger national funded project involving clinical trials. This study involves collaboration between engineers, ocular surface clinicians as well as specialists from the defence science organisation. When successfully completed, the project will increase the capability of Singapore Eye Research Institute and Singapore National Eye Centre to support future industry and academic research in the ocular surface.

Eligibility Criteria

Inclusion Criteria

must have undergone screening examination

Exclusion Criteria

unable to go to the DSO laboratory or undergo any of the study procedures

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01448356). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.