N/A
Completed N=10
Controlled Adverse Environment: A Pilot Study to Evaluate Tear Film Stability and Tear Evaporation
Environmental Exposure
Source: ClinicalTrials.gov NCT01448356 ↗
Enrolled (actual)
10
Serious AEs
0.0%
Results posted
Dec 2012
Primary outcomePrimary: Tear Evaporation Rate — 39.0; 44.8; 30.6; 26.7 Watt/meter^2
Summary
Dry eye and ocular surface disease account for a lot of morbidity and socio-economic burden in Asia and the rest of the world. This is a small pilot study to evaluate tear function under different conditions of humidity and temperature. This data will be useful for designing future trials in ocular surface and dry eye. The data will likely be used to propose a larger national funded project involving clinical trials. This study involves collaboration between engineers, ocular surface clinicians as well as specialists from the defence science organisation. When successfully completed, the project will increase the capability of Singapore Eye Research Institute and Singapore National Eye Centre to support future industry and academic research in the ocular surface.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Tear Evaporation Rate |
39.0; 44.8; 30.6; 26.7 | — |
| SECONDARY Tear Film Break up Time |
5.9; 4.4; 5.0; 4.6 | — |
Eligibility Criteria
Inclusion Criteria
- must have undergone screening examination
Exclusion Criteria
- unable to go to the DSO laboratory or undergo any of the study procedures
Data sourced from ClinicalTrials.gov (NCT01448356). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.