N/A
N=20
Effect of Thiamine on Oxygen Utilization (VO2) in Critical Illness
Acute Respiratory Failure
Bottom Line
View on ClinicalTrials.gov: NCT01462279 ↗Enrolled (actual)
20
Serious AEs
0.0%
Results posted
Nov 2016
Primary outcome: Primary: Improvement in VO2 — 16.9 ml/min
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Thiamine (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Beth Israel Deaconess Medical Center
- Primary completion
- Oct 2012
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Improvement in VO2 |
16.9 | — |
| SECONDARY Improvement in Hemodynamics |
— | — |
Summary
The objective of this study is to determine the effect of thiamine therapy on oxygen consumption in critically-ill patients. The investigators will evaluate this by measuring VO2 before and after thiamine administration in patients admitted to the ICU and requiring mechanical ventilation.
Eligibility Criteria
Inclusion Criteria
- Adult patients (age > 18 years) admitted to an ICU
- Mechanically ventilated
Exclusion Criteria
- Unstable ventilator settings during measurement of VO2
- Temp > 100 at time of VO2 measurement
- FIO2 > 60%
- Endotracheal cuff leak, chest tube, or other evident source of air leak
- Thiamine supplementation within 24 hours prior to study enrollment
Data sourced from ClinicalTrials.gov (NCT01462279). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.