N/A N=20 Randomized Single-blind Treatment

Oral Contraceptives and Subantimicrobial Doxycycline: Effect on Endometrial Matrix Metalloproteinases

Breakthrough Bleeding

Bottom Line

View on ClinicalTrials.gov: NCT01469585 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Dec 2020

Primary outcome: Primary: Endometrial Matrix Metalloproteinase Expression by Gel Densitometry — 1.33; 2.49 relative expression

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Doxycycline (Drug)
Age: Adult · 18+ yrs
Sex: Female
Sponsor: University of Hawaii
Primary completion: May 2012

Outcome Measures

Outcome	Result	p-value
PRIMARY Endometrial Matrix Metalloproteinase Expression by Gel Densitometry	1.33; 2.49	—
SECONDARY Matrix Metalloproteinase Expression and Activity by Gel Densitometry	1.52; 1.98	—

Summary

The purpose of this study is to compare the effects (good and bad) of subantimicrobial dose doxycycline on the irregular bleeding women experience when taking continuous oral contraceptive pills. This research is being done because currently, there is no effective treatment for this condition. Findings from this study could help to decrease the side effects of birth control pills and decrease unplanned pregnancies.

Eligibility Criteria

Inclusion Criteria

Women between the ages 18 and 45 who are ovulatory as demonstrated by a pre-treatment Progesterone (P) greater than or equal to 3.0 ng/mL prior to oral contraceptive use

Exclusion Criteria

Women with any absolute contraindications to ethinyl estradiol and levonorgestrel;
Women who are pregnant or breastfeeding
Use of oral contraceptives, patch, ring, intrauterine or implantable hormonal contraception within 4-weeks;
Medroxyprogesterone acetate use within six months;
Current use of drugs that interfere with sex steroid metabolism.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01469585). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.