N/A N=9

Effects of Obesity Surgery on Renal Function

Impaired Renal Function

Bottom Line

View on ClinicalTrials.gov: NCT01507350 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Oct 2020

Primary outcome: Primary: Changes in Glomerular Renal Function After Weight Loss Surgery as Measured by 51Cr-EDTA Clearance — 0 Participants

Study Design & Population

Study type: Observational
Phase: N/A
Interventions: —
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Imperial College London
Primary completion: Jun 2016

Outcome Measures

Outcome	Result	p-value
PRIMARY Changes in Glomerular Renal Function After Weight Loss Surgery as Measured by 51Cr-EDTA Clearance	—	—

Summary

Increasing risk of impaired renal function as a result of obesity is well known. Early data has postulated that weight loss might improve kidney function, but the evidence is rather limited due to the difficulties in measuring glomerular filtration rate(GFR) after weight loss. Cystatin C, GFR measurement using Cockcroft-Gault (CCG) and Modification of Diet in Renal Disease (MDRD) equations, have all yield conflicting results after weight loss surgery. The study aim to assess: 1. use of 51Cr-EDTA Clearance as the methodological gold standard in evaluating changes in renal function before and after weight loss surgery. 2. the reliability of using MDRD, CCG and Cystatin C in measuring GFR after weight loss surgery 3. the differences in alterations in renal function dependent on the surgical procedures( gastric bypass, gastric band, sleeve gastrectomy). 4. the use of urine albumin/creatinine ratio in detecting alterations in microalbuminuria.

Eligibility Criteria

Inclusion Criteria

Patients with a BMI of >35kg/m2 approved for obesity surgery based on the NICE criteria.
Patients with a GFR <60 mL/min/1.73 m2

Exclusion Criteria

Allergy to chromium

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Data sourced from ClinicalTrials.gov (NCT01507350). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.