Phase 4
Completed N=24
Effect of Aliskiren and Hydrochlorothiazide on Kidney Oxygenation in Patients With Hypertension
Source: ClinicalTrials.gov NCT01519635 ↗Enrolled (actual)
24
Serious AEs
0.0%
Results posted
Sep 2019
Primary outcomePrimary: Renal Oxygenation Changes After Chronic Treatment With Aliskiren or Hydrochlorothiazide — 20.5; 19.5; 19.5; 20.5 1/sec
◆ Published Evidence
Emerging
12citations · ~1 / year
Comparative Effect of a Renin Inhibitor and a Thiazide Diuretic on Renal Tissue Oxygenation in Hypertensive Patients.
Summary
The goal of this project is to evaluate the chronic effect (8 weeks) of RASILEZ 300mg (aliskiren) on renal tissue oxygenation in patients with stage 1-2 hypertension, and to compare the chronic effect (8 weeks) of RASILEZ 300mg (aliskiren) on renal tissue oxygenation in patients with stage 1-2 hypertension with these effects with those of ESIDREX 25mg (hydrochlorothiazide).
Linked Publications
-
Comparative Effect of a Renin Inhibitor and a Thiazide Diuretic on Renal Tissue Oxygenation in Hypertensive Patients.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Renal Oxygenation Changes After Chronic Treatment With Aliskiren or Hydrochlorothiazide |
20.5; 19.5; 19.5; 20.5 | — |
Eligibility Criteria
Inclusion Criteria
- Tolerance to study drugs
- Age > 18 years
- Arteria hypertension stage 1-2 (blood pressure: 140/90 and 180/110 mm Hg)
- Normal renal function
- Availability to give informed consent
Exclusion Criteria
- Intolerance to study drugs
- Renal artery stenosis
- Hyperkalaemia > 5.0 mmol/l
- Contra-indications to the use of PAH, inulin or Lithium
- Asthma
- Pychiatric illness
- No estimated easy vascular venous access for placement of two peripherical venous catheters in forearms
- Contra-indication to MRI-imaging: Claustrophobia or Pacemaker or other implanted metal device
Data sourced from ClinicalTrials.gov (NCT01519635) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.