N/A N=252 Randomized Health Services Research

Antimicrobial Stewardship Through MRSA Diagnosis in Emergency Department (ED) Patients With Abscesses

Cutaneous Abscess

Bottom Line

View on ClinicalTrials.gov: NCT01523899 ↗

Enrolled (actual)

252

Serious AEs

—

Results posted

Sep 2017

Primary outcome: Primary: Number of Participants With Antibiotic Usage at the Time of the ED Visit — 97; 96 Participants

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Xpert MRSA/SA SSTI (Device); Standard culture (Diagnostic_test)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: George Washington University
Primary completion: Jan 2015

Outcome Measures

Outcome	Result	p-value
PRIMARY Number of Participants With Antibiotic Usage at the Time of the ED Visit	97; 96	—
SECONDARY Participant Clinical Improvement Post-treatment at One Week	91; 94	>0.05
SECONDARY Clinical Outcome at One or Three Months	26; 24	—

Summary

This study expands upon pilot data for feasibility since May 2011. The study aims to evaluate the effect of rapid test availability on use of targeted spectrum antibiotics for non-MRSA abscesses in ambulatory patients in the Emergency Department (ED). The multi-institutional study will assess the feasibility of providing the GeneXpert® MRSA/SA SSTI assay to the ED and evaluate the impact of delivering the test result to clinicians in real-time on patient management decisions regarding the use of antimicrobial agents. Patients are randomized to standard culture (control arm) or to the GeneXpert® assay plus standard culture.

Eligibility Criteria

Inclusion Criteria

adults 18 years or older with community onset abscess

Exclusion Criteria

previous treatment for same abscess in past 14 days
postoperative infection
inability to provide informed consent

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01523899). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.